Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
| Location | 1385644..1386332 | Replicon | chromosome |
| Accession | NZ_CP095021 | ||
| Organism | Mycobacterium tuberculosis strain SGF0422017 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | G0THR7 |
| Locus tag | MUW66_RS06605 | Protein ID | WP_003406304.1 |
| Coordinates | 1385901..1386332 (+) | Length | 144 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0THR6 |
| Locus tag | MUW66_RS06600 | Protein ID | WP_003406302.1 |
| Coordinates | 1385644..1385904 (+) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUW66_RS06580 (MUW66_06580) | 1381221..1382045 | + | 825 | WP_003900298.1 | trehalose ABC transporter permease SugB | - |
| MUW66_RS06585 (MUW66_06585) | 1382050..1383231 | + | 1182 | WP_003406299.1 | trehalose ABC transporter ATP-binding protein SugC | - |
| MUW66_RS06590 (MUW66_06590) | 1383308..1384408 | - | 1101 | WP_003406300.1 | magnesium/cobalt transporter CorA | - |
| MUW66_RS06595 (MUW66_06595) | 1384579..1385568 | + | 990 | WP_003406301.1 | malate dehydrogenase | - |
| MUW66_RS06600 (MUW66_06600) | 1385644..1385904 | + | 261 | WP_003406302.1 | type II toxin-antitoxin system antitoxin VapB33 | Antitoxin |
| MUW66_RS06605 (MUW66_06605) | 1385901..1386332 | + | 432 | WP_003406304.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| MUW66_RS06610 (MUW66_06610) | 1386355..1387938 | - | 1584 | WP_009940130.1 | PE family protein | - |
| MUW66_RS06615 (MUW66_06615) | 1388118..1388978 | + | 861 | WP_003900301.1 | glycine betaine ABC transporter substrate-binding protein | - |
| MUW66_RS06620 (MUW66_06620) | 1389059..1389889 | - | 831 | WP_003898788.1 | SDR family NAD(P)-dependent oxidoreductase | - |
| MUW66_RS06625 (MUW66_06625) | 1389946..1390239 | - | 294 | WP_003898789.1 | type II toxin-antitoxin system mRNA interferase RelE | - |
| MUW66_RS06630 (MUW66_06630) | 1390236..1390505 | - | 270 | WP_003406322.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 144 a.a. Molecular weight: 15873.08 Da Isoelectric Point: 5.8838
>T241032 WP_003406304.1 NZ_CP095021:1385901-1386332 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE
Download Length: 432 bp
>T241032 NZ_LT906450:c2903500-2902931 [Rhodococcus rhodochrous]
ATGAGACGTCTGGATCTGATCGTCGGTCCCAACGGTTCCGGCAAGTCGACGTTCGTCGAGTTGTCCCTCGCTCCCCTGCT
GCCGTGCAGCGTGTTCGTCAACGCGGATGTGATCGCGCGGCAGCGCTGGCCCGACCGGGCGGAGGAGATGTCGTACGAGG
CGGCGCAGCTCGCCGCGGCGGCGCGGGACCGGCTGCTGCGGCAGGGCCGGTCGTTCATCGCGGAGACGGTGTTCTCGCAT
CCGTCGAAGCTGGAGTTGATCGACCGCGCGCACGAGGCGGGATTCACGGTGGTGCTGCACGTGATGCTGGTGCCCGAGAC
GATGTCGGTGCTGCGCGTGCAGCATCGGGTGGCCGCAGGTGGGCATGCGGTGCCGGAGGACAAGATCCGGGCGCGCTATC
GACGGTTGTGGCCGCTGGTGGCCGAGGCGATCGGCCGCGCCGATCAGGCGTCGGTGTACGACACGGCGTCCGGGACCCCG
GTGGTGGTGGCGCGGTTCGCCGGCGGGGTGCCGGTCGGTGCGGTGCGCTGGCCGGGATGGGCGCCGGCGGCGCTCACCGG
GCTCGGCTGA
ATGAGACGTCTGGATCTGATCGTCGGTCCCAACGGTTCCGGCAAGTCGACGTTCGTCGAGTTGTCCCTCGCTCCCCTGCT
GCCGTGCAGCGTGTTCGTCAACGCGGATGTGATCGCGCGGCAGCGCTGGCCCGACCGGGCGGAGGAGATGTCGTACGAGG
CGGCGCAGCTCGCCGCGGCGGCGCGGGACCGGCTGCTGCGGCAGGGCCGGTCGTTCATCGCGGAGACGGTGTTCTCGCAT
CCGTCGAAGCTGGAGTTGATCGACCGCGCGCACGAGGCGGGATTCACGGTGGTGCTGCACGTGATGCTGGTGCCCGAGAC
GATGTCGGTGCTGCGCGTGCAGCATCGGGTGGCCGCAGGTGGGCATGCGGTGCCGGAGGACAAGATCCGGGCGCGCTATC
GACGGTTGTGGCCGCTGGTGGCCGAGGCGATCGGCCGCGCCGATCAGGCGTCGGTGTACGACACGGCGTCCGGGACCCCG
GTGGTGGTGGCGCGGTTCGCCGGCGGGGTGCCGGTCGGTGCGGTGCGCTGGCCGGGATGGGCGCCGGCGGCGCTCACCGG
GCTCGGCTGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9918.25 Da Isoelectric Point: 6.4755
>AT241032 WP_003406302.1 NZ_CP095021:1385644-1385904 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR
Download Length: 261 bp
>AT241032 NZ_LT906450:c2903883-2903497 [Rhodococcus rhodochrous]
ATGACGTCGTCCACCGACAAGGTCACCCGCTTCGACGCCGAGCTCGTCGACAGCGCCATCGCCGAGGGCGGCCGCCAGAA
CCGCACCGGACGCCAGCAACTCGAATACTGGGCCCGCATCGGCCGCGCGATGACCGCCCACGAGACCGCCTCCCTGCATC
GGGTGCACGAGGCGCTGGCCGGGACGCGGGAGCTGAGTGAGCTCACCGCCGCGGAGGGGCGCCTGTTCGACGCCGAGATC
GACGCGCGCCTGGCGGACGGGCTGGCCCGCACCGACTACGCCGAGATTCTCGCCGCACGTGGGGTCACCACGGTGGTGCT
CGACGACGAGGGCCGGCTGGTCGAGCAGCATCCCGACGGTAGTCGCCGGGTGCTCGACGACGCATGA
ATGACGTCGTCCACCGACAAGGTCACCCGCTTCGACGCCGAGCTCGTCGACAGCGCCATCGCCGAGGGCGGCCGCCAGAA
CCGCACCGGACGCCAGCAACTCGAATACTGGGCCCGCATCGGCCGCGCGATGACCGCCCACGAGACCGCCTCCCTGCATC
GGGTGCACGAGGCGCTGGCCGGGACGCGGGAGCTGAGTGAGCTCACCGCCGCGGAGGGGCGCCTGTTCGACGCCGAGATC
GACGCGCGCCTGGCGGACGGGCTGGCCCGCACCGACTACGCCGAGATTCTCGCCGCACGTGGGGTCACCACGGTGGTGCT
CGACGACGAGGGCCGGCTGGTCGAGCAGCATCCCGACGGTAGTCGCCGGGTGCTCGACGACGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|