Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1230663..1231294 Replicon chromosome
Accession NZ_CP095021
Organism Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag MUW66_RS05880 Protein ID WP_003405820.1
Coordinates 1230663..1230974 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag MUW66_RS05885 Protein ID WP_003405836.1
Coordinates 1230974..1231294 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW66_RS05860 (MUW66_05860) 1226144..1227568 - 1425 WP_003405805.1 class II fumarate hydratase -
MUW66_RS05865 (MUW66_05865) 1227599..1228687 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
MUW66_RS05870 (MUW66_05870) 1228743..1229387 + 645 WP_003915494.1 DUF4245 domain-containing protein -
MUW66_RS05875 (MUW66_05875) 1229394..1230551 - 1158 WP_003898727.1 AI-2E family transporter -
MUW66_RS05880 (MUW66_05880) 1230663..1230974 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
MUW66_RS05885 (MUW66_05885) 1230974..1231294 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
MUW66_RS05890 (MUW66_05890) 1231304..1232840 + 1537 Protein_1159 carboxylesterase/lipase family protein -
MUW66_RS05895 (MUW66_05895) 1232847..1233959 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
MUW66_RS05900 (MUW66_05900) 1233969..1234226 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
MUW66_RS05905 (MUW66_05905) 1234216..1235463 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
MUW66_RS05910 (MUW66_05910) 1235460..1236098 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T241030 WP_003405820.1 NZ_CP095021:c1230974-1230663 [Mycobacterium tuberculosis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T241030 NZ_LT906447:1029118-1029324 [Staphylococcus piscifermentans]
ATGCAAAATAGTGTGATAAAAATTGATGGTTTAGAAACTGAAGAAGCACAACATAAATTACATCAACATCTTAGTGAAAT
GACTGGCGTTTCTGCGGTACAAGTAGATATGGATTCCAATGAAATCCGTATTAGTTATGAAACACCTGTCAATTTAAATA
ATCTTGAAAAAGAAATTTATGATGCAGGCTATCAAATATTAAATTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT241030 WP_003405836.1 NZ_CP095021:c1231294-1230974 [Mycobacterium tuberculosis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT241030 NZ_LT906447:1028812-1029105 [Staphylococcus piscifermentans]
ATGACTGAAAATGATAAAGCGCATCATTCTGAACAAATTAAATCTAACTTAAAAGCACGTCTCAATCGTATTGAAGGACA
AGTAAGAGCAATTAATCGGATGATTGACGAAGATGTTTATTGTGATGATGTACTCACGCAAATACGTGCTACACGTTCAG
CATTGAATAGTGTGGCAGTTAAGCTGCTCGATCATCATATGAAAGGCTGTATTATGCATAAAGTAGATGATGGACATGCA
GAGGAAGCGATGGAAGAATTATTAGTAACCGTACAAAAATTGATTAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References