24103

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2453229..2453870 Replicon chromosome
Accession NC_012962
Organism Photorhabdus asymbiotica

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PAU_RS10570 Protein ID WP_015834328.1
Coordinates 2453229..2453411 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PAU_RS10575 Protein ID WP_015834329.1
Coordinates 2453463..2453870 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAU_RS10555 2448597..2450288 + 1692 WP_015834324.1 exochitinase -
PAU_RS10560 2450371..2451618 - 1248 WP_015834325.1 FAD-dependent monooxygenase -
PAU_RS25240 2452160..2452273 + 114 Protein_2089 DNA gyrase -
PAU_RS10565 2452473..2452916 + 444 WP_015834327.1 cupin domain-containing protein -
PAU_RS10570 2453229..2453411 + 183 WP_015834328.1 type II toxin-antitoxin system HicA family toxin Toxin
PAU_RS10575 2453463..2453870 + 408 WP_015834329.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PAU_RS10580 2454091..2455842 - 1752 WP_015834330.1 arsenical pump-driving ATPase -
PAU_RS10585 2455856..2456221 - 366 WP_015834331.1 arsenite efflux transporter metallochaperone ArsD -
PAU_RS10590 2456272..2456607 - 336 WP_015834332.1 metalloregulator ArsR/SmtB family transcription factor -
PAU_RS10595 2456784..2458019 - 1236 WP_015834333.1 HlyD family efflux transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6602.71 Da        Isoelectric Point: 10.6679

>T24103 WP_015834328.1 NC_012962:2453229-2453411 [Photorhabdus asymbiotica]
MSSDELIKQIKAVGWNFVRANGSHHVFEKSGEPSPIIIPHPRKDLAVGTLNKILKQAGLK

Download         Length: 183 bp

>T24103 NC_012962:2453229-2453411 [Photorhabdus asymbiotica]
ATGTCTAGCGATGAACTAATAAAGCAAATCAAAGCGGTTGGTTGGAATTTTGTGCGAGCCAATGGTTCGCACCATGTTTT
TGAGAAATCAGGGGAACCCAGCCCGATAATAATTCCGCATCCGCGCAAAGATTTGGCGGTCGGGACGCTCAATAAAATAC
TTAAACAAGCAGGACTGAAATAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15213.90 Da        Isoelectric Point: 4.7483

>AT24103 WP_015834329.1 NC_012962:2453463-2453870 [Photorhabdus asymbiotica]
MRYPIYLHQADDGSFSGFVPDVIGCYFAGDTIDDAISDAQNALDTYFEYMSEKGEAPVQARTVADHLSNEDCTGGSWAYV
DMDLTKYDGKAIKLNITMPQFLLGRIDKYVNSHREYHSRSGFLAELARRELSKHS

Download         Length: 408 bp

>AT24103 NC_012962:2453463-2453870 [Photorhabdus asymbiotica]
ATGAGATATCCTATTTATTTACATCAGGCTGACGACGGATCGTTTTCCGGTTTTGTGCCAGACGTGATCGGATGTTACTT
TGCTGGCGATACCATTGACGACGCTATTAGCGATGCTCAAAACGCATTAGATACTTATTTTGAATACATGAGCGAAAAGG
GTGAGGCTCCAGTACAAGCCAGAACTGTTGCTGACCATCTAAGCAATGAAGATTGCACCGGCGGTAGTTGGGCTTATGTT
GATATGGATTTAACTAAATACGATGGAAAAGCCATCAAGCTAAACATTACTATGCCTCAATTTTTGTTGGGTAGAATTGA
TAAATACGTGAACTCACATCGTGAGTATCATAGCCGCAGCGGATTCTTGGCTGAATTGGCTCGGCGTGAGCTGTCGAAAC
ACTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References