Detailed information of TA system TA241028

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 1014513..1015132
• Replicon: chromosome
• Accession: NZ_CP095021
• Organism: Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: MUW66_RS04805
• Protein ID: WP_003404726.1
• Coordinates: 1014698..1015132 (+)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: P9WJ06
• Locus tag: MUW66_RS04800
• Protein ID: WP_003898641.1
• Coordinates: 1014513..1014692 (+)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUW66_RS04785 (MUW66_04785)	1009986..1011566	+	1581	WP_244743755.1	serine hydrolase	-
MUW66_RS04790 (MUW66_04790)	1011563..1013956	+	2394	WP_003898639.1	cation-translocating P-type ATPase	-
MUW66_RS04795 (MUW66_04795)	1014229..1014387	+	159	WP_003404720.1	hypothetical protein	-
MUW66_RS04800 (MUW66_04800)	1014513..1014692	+	180	WP_003898641.1	antitoxin	Antitoxin
MUW66_RS04805 (MUW66_04805)	1014698..1015132	+	435	WP_003404726.1	SRPBCC family protein	Toxin
MUW66_RS04810 (MUW66_04810)	1015230..1016003	+	774	WP_003404735.1	VOC family protein	-
MUW66_RS04815 (MUW66_04815)	1016068..1016517	+	450	WP_003404738.1	hypothetical protein	-
MUW66_RS04820 (MUW66_04820)	1016652..1016882	-	231	WP_003898642.1	hypothetical protein	-
MUW66_RS04825 (MUW66_04825)	1017049..1018557	-	1509	WP_003404742.1	carotenoid oxygenase family protein	-
MUW66_RS04830 (MUW66_04830)	1018559..1019797	-	1239	WP_031721797.1	acetyl-CoA acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-50)

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15754.47 Da
• Isoelectric Point: 9.7977

>T241028 WP_003404726.1 NZ_CP095021:1014698-1015132 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Nucleotide

• Length: 435 bp

>T241028 NZ_LT906445:c1983313-1983128 [Veillonella parvula]
TTGACTACACCTAAAGAATTGATGAAGGATTTAAAAAAAGATGGTTGGTATATTGATAGAATTAAAGGCTCGCATCATAT
ACTAAAGCATCCAATAAAAGCTGGTCGTGTAACGATTCCGCTACATAAGGAAGATTTAAAGCCTAAAACATTACAAACAA
TCTTGAAACAAGCGGGGCTTAAATAG

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6403.07 Da
• Isoelectric Point: 4.5393

>AT241028 WP_003898641.1 NZ_CP095021:1014513-1014692 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Nucleotide

• Length: 180 bp

>AT241028 NZ_LT906445:c1983059-1982661 [Veillonella parvula]
ATGAGAAAGGAAATGTACCCAGCTATCTTTAGTACAGATGGTAAAAATGGATATACGGTAAGTTTTCCAGATTTATTAGG
CTGTGTAACTGAAGGCGATACTTTATGTGAAGCCGTAGAGATGGCTGAAGATGCACTAGGTATTTACTTGTATTCATTGA
GTGAAGATGGCGAGGAATTTCCAGAAGCAAGTAATCCAATCGATATTAAATGTAATAAAGGTGAATTCATAGATTTAGTA
AAATGGGATGAAGAGGAATATTTAAAAAGAACCGATAATAAAGCTGTAAAAAAGACCCTTACAATACCAAGCTGGTTAAA
TCATAAAGCTGAAGAGAAGCAACTTAATTTTTCACAAATTTTACAGAGAGCATTAAAGCAAGAGTTAGAATTAGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A045KDK5