Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 753598..754138 | Replicon | chromosome |
| Accession | NZ_CP095021 | ||
| Organism | Mycobacterium tuberculosis strain SGF0422017 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | P9WII0 |
| Locus tag | MUW66_RS03465 | Protein ID | WP_003403376.1 |
| Coordinates | 753598..753906 (-) | Length | 103 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | G0TQE0 |
| Locus tag | MUW66_RS03470 | Protein ID | WP_003403381.1 |
| Coordinates | 753893..754138 (-) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUW66_RS03440 (MUW66_03440) | 748913..750418 | + | 1506 | WP_003403360.1 | carotenoid cleavage oxygenase | - |
| MUW66_RS03445 (MUW66_03445) | 750499..751509 | + | 1011 | WP_003911248.1 | ABC transporter ATP-binding protein | - |
| MUW66_RS03450 (MUW66_03450) | 751897..752280 | - | 384 | WP_003403365.1 | ribonuclease VapC6 | - |
| MUW66_RS03455 (MUW66_03455) | 752375..752530 | - | 156 | WP_003403368.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| MUW66_RS03460 (MUW66_03460) | 752606..753322 | - | 717 | WP_003403371.1 | CPBP family intramembrane metalloprotease | - |
| MUW66_RS03465 (MUW66_03465) | 753598..753906 | - | 309 | WP_003403376.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| MUW66_RS03470 (MUW66_03470) | 753893..754138 | - | 246 | WP_003403381.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
| MUW66_RS03475 (MUW66_03475) | 754248..754685 | - | 438 | WP_003403386.1 | type II toxin-antitoxin system VapC family toxin | - |
| MUW66_RS03480 (MUW66_03480) | 754682..754936 | - | 255 | WP_003911263.1 | antitoxin VapB7 | - |
| MUW66_RS03485 (MUW66_03485) | 755050..757413 | + | 2364 | WP_003901895.1 | arylsulfatase AtsD | - |
| MUW66_RS03490 (MUW66_03490) | 757476..757802 | + | 327 | WP_003403401.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| MUW66_RS03495 (MUW66_03495) | 757714..758052 | + | 339 | WP_003403405.1 | PIN domain-containing protein | - |
| MUW66_RS03500 (MUW66_03500) | 758049..758222 | + | 174 | WP_003898549.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 103 a.a. Molecular weight: 11320.10 Da Isoelectric Point: 11.6554
>T241024 WP_003403376.1 NZ_CP095021:c753906-753598 [Mycobacterium tuberculosis]
MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRR
ITRLSPARLHEACQTLRASTGC
MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRR
ITRLSPARLHEACQTLRASTGC
Download Length: 309 bp
>T241024 NZ_LT906442:2308929-2309435 [Legionella waltersii]
ATGGTTGATAATTCAATAATAACAATAAATGGCTGGGTTATTTTATGCCATCCTCTTTTTTTGCAACAAGTAGAGGCATT
GGCTAATGAGGTAGAAAATGCAAAAGAAAAGGACCCTTCAAATTTTCATACACGAAACTCGACAAAAAAATTAGCAGCCA
TTGCTAAATTAGCTTTTGAAAAAATTCCAAACGATCCTGCAGCTACAGAATTTCGACAAGGATCAACATTAGGAAATAAC
CACAAACATTGGTTTCGAGCTAAATTTTTTCAGCAATATCGATTATTTTTTAGATACCATCAAGAAAGTAAAATAATTAT
TTATGCTTGGGTTAATGATGACAGTTCTAAAAGAGCATATGAGAGTAAAGCAGATGCTTCTCATATTTTTCGAAAGATGC
TGGAAAATGGACATCCTCCAGATAATTGGGATGAATTACTTAAAGAAGCAAATAACACTTCGTTAATGAAAAAATTGACT
ACTAGTTTGGATGCTTTGAAAAGTTAA
ATGGTTGATAATTCAATAATAACAATAAATGGCTGGGTTATTTTATGCCATCCTCTTTTTTTGCAACAAGTAGAGGCATT
GGCTAATGAGGTAGAAAATGCAAAAGAAAAGGACCCTTCAAATTTTCATACACGAAACTCGACAAAAAAATTAGCAGCCA
TTGCTAAATTAGCTTTTGAAAAAATTCCAAACGATCCTGCAGCTACAGAATTTCGACAAGGATCAACATTAGGAAATAAC
CACAAACATTGGTTTCGAGCTAAATTTTTTCAGCAATATCGATTATTTTTTAGATACCATCAAGAAAGTAAAATAATTAT
TTATGCTTGGGTTAATGATGACAGTTCTAAAAGAGCATATGAGAGTAAAGCAGATGCTTCTCATATTTTTCGAAAGATGC
TGGAAAATGGACATCCTCCAGATAATTGGGATGAATTACTTAAAGAAGCAAATAACACTTCGTTAATGAAAAAATTGACT
ACTAGTTTGGATGCTTTGAAAAGTTAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9169.01 Da Isoelectric Point: 4.2070
>AT241024 WP_003403381.1 NZ_CP095021:c754138-753893 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R
Download Length: 246 bp
>AT241024 NZ_LT906442:2308582-2308929 [Legionella waltersii]
ATGGCTAGATTACTACAAACCGAATCCACCCTCACAGATCGATATCAAACAACTGTACCAGATGCTGTGAGAAAAGCCCT
GCATCTAGGAAAAAGAGATAAAATTCGATACACCGTTCAATCTGACGGTCATGTTCTTATGACTCGAGCAGAGGAAGAGG
AAGATCCAGTAATTGCTGAATTTTTGAATTTCATTGCTAAAGACATTCAAAATAACCCAAAAAATCTGACAACTTTAAAT
CAGGATTTAGTAACTCGCATCAACTCTTTAGTTGCAAATGTTGAAGTCAATTTAGATGAACCTTTAACCGAGGATGAACA
ATTAACTGAAAACCGAGTAACTCGCTAA
ATGGCTAGATTACTACAAACCGAATCCACCCTCACAGATCGATATCAAACAACTGTACCAGATGCTGTGAGAAAAGCCCT
GCATCTAGGAAAAAGAGATAAAATTCGATACACCGTTCAATCTGACGGTCATGTTCTTATGACTCGAGCAGAGGAAGAGG
AAGATCCAGTAATTGCTGAATTTTTGAATTTCATTGCTAAAGACATTCAAAATAACCCAAAAAATCTGACAACTTTAAAT
CAGGATTTAGTAACTCGCATCAACTCTTTAGTTGCAAATGTTGAAGTCAATTTAGATGAACCTTTAACCGAGGATGAACA
ATTAACTGAAAACCGAGTAACTCGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BSE5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TQE0 |