Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 751897..752530 Replicon chromosome
Accession NZ_CP095021
Organism Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag MUW66_RS03450 Protein ID WP_003403365.1
Coordinates 751897..752280 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag MUW66_RS03455 Protein ID WP_003403368.1
Coordinates 752375..752530 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW66_RS03425 (MUW66_03425) 747189..747725 + 537 WP_003403341.1 50S ribosomal protein L10 -
MUW66_RS03430 (MUW66_03430) 747762..748154 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
MUW66_RS03435 (MUW66_03435) 748147..748842 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
MUW66_RS03440 (MUW66_03440) 748913..750418 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
MUW66_RS03445 (MUW66_03445) 750499..751509 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
MUW66_RS03450 (MUW66_03450) 751897..752280 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
MUW66_RS03455 (MUW66_03455) 752375..752530 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MUW66_RS03460 (MUW66_03460) 752606..753322 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
MUW66_RS03465 (MUW66_03465) 753598..753906 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
MUW66_RS03470 (MUW66_03470) 753893..754138 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
MUW66_RS03475 (MUW66_03475) 754248..754685 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
MUW66_RS03480 (MUW66_03480) 754682..754936 - 255 WP_003911263.1 antitoxin VapB7 -
MUW66_RS03485 (MUW66_03485) 755050..757413 + 2364 WP_003901895.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T241023 WP_003403365.1 NZ_CP095021:c752280-751897 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T241023 NZ_LT906441:c56662-56351 [Cutibacterium granulosum]
ATGCGTGAGATCTGTCTGGCTCGGATGGACAGGACTCGACCCGTTGTCGTCCTCACCCGTGAAGTGTCCCGTCAGGCAAT
GACCAAGGTCACCGTTGCTCCAGTCACGTCGACCATCAAGGGGCTGTGCAGCGAGGTACGCGTCGGCAAGGCCAACGGTC
TTGACCATGAGTCCGCGATTGCCCTGGACAATGTGTTGACGATCCCGGTGGATCGGCTCGGCCGAAGCATTGGTTTTCTC
ACCCCGGATCAGGAGAAGGCTCTTGCCCGTGCCTTCGTCATGGCATATGACCTTGAGCTTCCAGTGGCCTGA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT241023 WP_003403368.1 NZ_CP095021:c752530-752375 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT241023 NZ_LT906441:c56898-56665 [Cutibacterium granulosum]
ATGACGACACAGATCTCGGTTCGGCTTCCTGATGAGATGGTCTCCTTCCTTGATCGCTGTGTGTCCGAGGGGCGCGTTGC
CAGCCGTGCTGAGATCATCGCTGGAGCGGTGGAGCGTGAGATGCGTCGTGAAGCGGCGATGCGTGATGCAGCCATCCTCG
CCGAGGTCGGATCTGCAGATGATTTGGATGATCTTGTGGCATGGTCGGTGGAGCACCCGGAGATGGGGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References