Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 709162..709787 Replicon chromosome
Accession NZ_CP095021
Organism Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag MUW66_RS03230 Protein ID WP_003403218.1
Coordinates 709386..709787 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag MUW66_RS03225 Protein ID WP_003403213.1
Coordinates 709162..709389 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW66_RS03200 (MUW66_03200) 704341..704562 - 222 WP_003898525.1 DUF4926 domain-containing protein -
MUW66_RS03205 (MUW66_03205) 704704..705309 + 606 WP_003898526.1 hypothetical protein -
MUW66_RS03210 (MUW66_03210) 705328..707895 - 2568 WP_003901879.1 SEC-C metal-binding domain-containing protein -
MUW66_RS03215 (MUW66_03215) 707979..708728 + 750 WP_003898528.1 hypothetical protein -
MUW66_RS03220 (MUW66_03220) 708725..708967 + 243 WP_003403210.1 hypothetical protein -
MUW66_RS03225 (MUW66_03225) 709162..709389 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
MUW66_RS03230 (MUW66_03230) 709386..709787 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
MUW66_RS03235 (MUW66_03235) 709916..709999 + 84 Protein_641 galactose-1-phosphate uridylyltransferase -
MUW66_RS03240 (MUW66_03240) 710018..711099 + 1082 Protein_642 galactose-1-phosphate uridylyltransferase -
MUW66_RS03245 (MUW66_03245) 711096..712187 + 1092 WP_003900977.1 galactokinase -
MUW66_RS03250 (MUW66_03250) 712582..713646 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
MUW66_RS03255 (MUW66_03255) 713750..714697 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T241020 WP_003403218.1 NZ_CP095021:709386-709787 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T241020 NZ_LT906437:c1538933-1538751 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT241020 WP_003403213.1 NZ_CP095021:709162-709389 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT241020 NZ_LT906437:c1538649-1538248 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References