Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 695534..696180 Replicon chromosome
Accession NZ_CP095021
Organism Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ88
Locus tag MUW66_RS03125 Protein ID WP_003403137.1
Coordinates 695534..695947 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ89
Locus tag MUW66_RS03130 Protein ID WP_003403139.1
Coordinates 695944..696180 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW66_RS03105 (MUW66_03105) 691617..693167 + 1551 WP_003905349.1 MCE family protein -
MUW66_RS03110 (MUW66_03110) 693219..693611 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 -
MUW66_RS03115 (MUW66_03115) 693608..693865 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 -
MUW66_RS03120 (MUW66_03120) 694048..695283 - 1236 WP_003403128.1 ATP-binding protein -
MUW66_RS03125 (MUW66_03125) 695534..695947 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW66_RS03130 (MUW66_03130) 695944..696180 - 237 WP_003403139.1 type II toxin-antitoxin system antitoxin VapB27 Antitoxin
MUW66_RS03135 (MUW66_03135) 696284..696790 - 507 WP_003900973.1 two component system sensor kinase HK1 -
MUW66_RS03140 (MUW66_03140) 696904..697434 - 531 WP_003917320.1 two component system sensor kinase HK2 -
MUW66_RS03145 (MUW66_03145) 697418..698113 - 696 WP_003918099.1 two-component system response regulator TcrA -
MUW66_RS03150 (MUW66_03150) 698236..698547 + 312 WP_003403164.1 hypothetical protein -
MUW66_RS03155 (MUW66_03155) 698619..699569 + 951 WP_003900184.1 DUF1259 domain-containing protein -
MUW66_RS03160 (MUW66_03160) 699810..700394 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
MUW66_RS03165 (MUW66_03165) 700396..701106 + 711 Protein_627 IS607 family element RNA-guided endonuclease TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-126)

Antitoxin

SpoVT-AbrB domain

(3-43)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14786.14 Da        Isoelectric Point: 8.1405

>T241018 WP_003403137.1 NZ_CP095021:c695947-695534 [Mycobacterium tuberculosis]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA

Download         Length: 414 bp

>T241018 NZ_LT906435:c4150205-4149297 [Pandoraea sputorum]
ATGCAAGCCGAAGCCCATCAACACGAAGTGCCAGAAGACGATGTCGTTGCGCCCTTGCGCGCACGGCTGGACGCCTTTCC
GTACCGCACCGTCGCAACGCGTGCGGGCACTGTCGGCTATCGCTGTTCGGGCACCGGGAACGACGTCGGCGTGCCGGTCG
TGATGCTGCACGGCATCGGCTCCGGCGCAGCGTCCTGGCTGGCGCAGTTCGAGGCCACGGGCCTCGACGCGAAGCTTTAC
GCATGGGATGCGCCCGGCTACGGCGAGACGTCGAATGTCGCTGCTGCGCAACCTCATCCCGACGCCTATGCCGACGCTCT
CGAAGCGTGGCTCGATGCCCTCGGTCTGGATCGTGTGGCGCTGGCCGGTCATTCGCTGGGCGCAATCATGGCAACGAGGT
TTGCGAGCCGCGCGCCGCAACGCGTACGCGGTCTCTTTCTGTGCTCTCCCGCCAACGGCTATGGCCGCGCCGATGCCGAG
GTGCGCGTGTCCAAGCGCGACAGCCGTCTGGCGATGCTCGACAAGCTCGGCCCTGCGGGCATGGCGCGTGAGCGCAGCGA
CAACCTCGTTGCGCCCGGCGCCGCCGATCTGCCACGCGCGTGGGTGAAATGGAACATGTCGCGGGTGCTGCCGGTCGGTT
ACCGTCAGGCGACGCACCTGCTCTCGAATGGCGATGTCGCGGGCGACCTTGCACAGTACGTGAGTGCCAAGGCCGGTCCC
GTTGCGGTCGCCGTGGGCGCGCAGGACGGCATCACGCCGCCTGCTGCGTGCGAGGTCATCGCGAAAGTGGCGGGCGTGCC
ACTGCAAATCATCGACGGCGCAGGCCACGCGTCGTACATCGAAACGCCGGACGTTCTGAATGCTGCGCTCGCCGCGTGGC
TCGAACGTGTCGCGGCAGGGGAGCGCTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8212.41 Da        Isoelectric Point: 5.0351

>AT241018 WP_003403139.1 NZ_CP095021:c696180-695944 [Mycobacterium tuberculosis]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK

Download         Length: 237 bp

>AT241018 NZ_LT906435:c4149295-4148369 [Pandoraea sputorum]
ATGGCACCGGCCACACCGAAGCGCGAAGCGCTCACCGAAGACGACAATATGCAGGACGATCGAAACGTCTCGCCCGACGG
CGACGCTGTCGTCGAGGGCCCTGCCGAGTCCCGCTATCTCGTGCCGGGCCTAGAGCGCGGCCTGCGCATCCTCACCCAAT
TCTCGCCGCGCGAACCGGTGTTCAGTGCACCGGAACTGTCGCAACGGCTGGGCATTCCGCGCACGACCGTCTTCCGTCTG
CTGCAGACGCTCGAAGCCATGGGCTTTCTTGAGCGTGCGGGAAGCGAAAAGAACTTCCGTCTGGGCGTGGCCGTGCTGCG
TCTGGGCTTCGAATACCTCAGCTCGCTGGAACTGACCGACCTGGGCATTCCGATCATCGAGCGCCTGCGCGACGCCACGC
AACTGACGTCGCACATCGTGATTCGCGACGGCCGCGACATCGTGTTCGTCGCGAAGGCGCAAAGCGTCGCCGGCGTCTTC
AACTCGATCAAGGTCAACGTCGGCACGCGTCTGCCCGCGCACGCCACGGTGCACGGTCACGTGCTGATGGGCGATCTGAC
GCTCACCGAACTGCGCGCGCTGTATCCCGAGAAGACGCTGGAGAAATTCACGCCGCAGACGCCAGAGTCGCTCACCGAAC
TGTTCGAGCGTGTGCGCGAAGACGCCGAACGCGGCTATGCCGTGTCGGCCTCGTCGTTCGAGCGCGGCATCAGCGTGGTG
AGCGCGCCGGTGCGCAACGACGTGGGTCGCATCTGCGCCGCCATCACGGTCACGATTCCGCGCGCGAACATCGACGCATC
GATGCTCGACGCGGGCCTGATCGGTCAGGTGCGCGAAGCCGCCGATGCGCTCTCGCACCGTCTGAACTACCGCCCTGGCA
GCGACGGCAAGTCCACCCCCTACATGAAGTCACTGGGACTCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ88

Antitoxin

Source ID Structure
AlphaFold DB G0TQ89

References