Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 693219..693865 Replicon chromosome
Accession NZ_CP095021
Organism Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag MUW66_RS03110 Protein ID WP_003403122.1
Coordinates 693219..693611 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag MUW66_RS03115 Protein ID WP_003403125.1
Coordinates 693608..693865 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW66_RS03095 (MUW66_03095) 688881..690407 + 1527 WP_003403112.1 virulence factor Mce family protein -
MUW66_RS03100 (MUW66_03100) 690470..691612 + 1143 WP_003911253.1 virulence factor Mce family protein -
MUW66_RS03105 (MUW66_03105) 691617..693167 + 1551 WP_003905349.1 MCE family protein -
MUW66_RS03110 (MUW66_03110) 693219..693611 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
MUW66_RS03115 (MUW66_03115) 693608..693865 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
MUW66_RS03120 (MUW66_03120) 694048..695283 - 1236 WP_003403128.1 ATP-binding protein -
MUW66_RS03125 (MUW66_03125) 695534..695947 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
MUW66_RS03130 (MUW66_03130) 695944..696180 - 237 WP_003403139.1 type II toxin-antitoxin system antitoxin VapB27 -
MUW66_RS03135 (MUW66_03135) 696284..696790 - 507 WP_003900973.1 two component system sensor kinase HK1 -
MUW66_RS03140 (MUW66_03140) 696904..697434 - 531 WP_003917320.1 two component system sensor kinase HK2 -
MUW66_RS03145 (MUW66_03145) 697418..698113 - 696 WP_003918099.1 two-component system response regulator TcrA -
MUW66_RS03150 (MUW66_03150) 698236..698547 + 312 WP_003403164.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T241017 WP_003403122.1 NZ_CP095021:c693611-693219 [Mycobacterium tuberculosis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

>T241017 NZ_LT906435:1528107-1528385 [Pandoraea sputorum]
TTGATTGAAAATTTTAAATGCAGGGATACGGCACTCCTGTTTAGCGGGCGGCGCGTGACGCGCTGGCGTGCGGTCGAGTC
GGCCGCTATACGCAAGCTTCAGCAACTTCATGCGGCGGCAACACTGAGTTTCTTACGCGCGCCACCGGGTAACAGACTTG
AAGCGCTGCGTGGAGATCGTCTGGGGCAATACAGTATCCGGATCAACGATCAGTGGCGGTTGTGCTTCCGTTTTGACGCG
GGCACCGCTTCGGACGTCGAAATCGTCGACTACCACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT241017 WP_003403125.1 NZ_CP095021:c693865-693608 [Mycobacterium tuberculosis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp

>AT241017 NZ_LT906435:1528460-1528771 [Pandoraea sputorum]
ATGACCCGACAAGTACCGCTGGCAACACCGGGCGAGATTCTCGCGCAAGAGTGGCTCGGCCCGATGGGGATCTCGCAATA
CGCACTGGCCAAAGCCATTGACGTGCCCCCTCGCCGGATCAATGAGATCGTGCTCGGCAAACGGGCGATTACCGTCGATA
CCGCACTGCGTCTGGGGGCGTTCTTTGGCGTAGATGCGCAGAGTTGGCTCAATCTGCAAAATCAATACGATGCTGAAATT
GCGCGCGCGAACATGGTTGATGTTCTGAAGACGATCAAGCACCGCGCGCGGGCGTTGCTCGCAGCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References