Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 442557..443568 Replicon chromosome
Accession NZ_CP095021
Organism Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag MUW66_RS01915 Protein ID WP_003401859.1
Coordinates 442557..443150 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag MUW66_RS01920 Protein ID WP_003401860.1
Coordinates 443179..443568 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW66_RS01895 (MUW66_01895) 438206..439588 + 1383 WP_003898415.1 magnesium transporter -
MUW66_RS01900 (MUW66_01900) 439600..440634 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
MUW66_RS01905 (MUW66_01905) 440730..441413 + 684 WP_003401857.1 VTT domain-containing protein -
MUW66_RS01910 (MUW66_01910) 441402..442532 - 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
MUW66_RS01915 (MUW66_01915) 442557..443150 - 594 WP_003401859.1 zeta toxin family protein Toxin
MUW66_RS01920 (MUW66_01920) 443179..443568 - 390 WP_003401860.1 hypothetical protein Antitoxin
MUW66_RS01925 (MUW66_01925) 443649..444860 - 1212 WP_003401861.1 VWA domain-containing protein -
MUW66_RS01930 (MUW66_01930) 444866..445468 - 603 WP_003898417.1 SRPBCC family protein -
MUW66_RS01935 (MUW66_01935) 445482..446378 - 897 WP_003898418.1 MoxR family ATPase -
MUW66_RS01940 (MUW66_01940) 446375..446968 - 594 WP_003401864.1 NTP transferase domain-containing protein -
MUW66_RS01945 (MUW66_01945) 446965..447720 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T241014 WP_003401859.1 NZ_CP095021:c443150-442557 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T241014 NZ_LT906435:156138-156557 [Pandoraea sputorum]
ATGTACTTACTGGATACCAACGTCATTAGCGAAAGCCGAAAGAGGGGAGGCGGCGATGAAGGGGTTCAGCGCTTCATGCG
AATGACCGATCGGCGTAAGGCACCTCGCTTTCTATCCGTCATTACGATGGGCGAGCTGCAACGTGGGGTTAAGGTGCTCC
GGCACAGAAACGATGTTCGACAGGCATCGCTAATCGAGTCTTGGTTGGCCCAACTAAGACTCGATTACGCCAACGACATA
CTGCCGGTCGATCAGGAGATCTGCAACGTTTGGGCACGCATGCGCGTGCCCAACGCAGCGCACCCAATCGATAAATTGAT
TGCGGCCACAGCGTTGGTGCACAAGTTGATCGTCGTCACACGCAACGTCAAAGATTTTTCCAACACAGGTGTGGAGGTGT
ACAACCCGTTTCAGCCATAG

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT241014 WP_003401860.1 NZ_CP095021:c443568-443179 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT241014 NZ_LT906435:155923-156123 [Pandoraea sputorum]
ATGATGCTGATTGAAGGTATCGACGAGCAACTGATGCGGTCGATTGAGTCGAGAGCTGCCGAGGGTGGCAGAACGCCGGA
AGAGGAAGTTCTGATGATTTTGGATCGTATGGCGAGGGTGCCGAGATTCCGGTCGTTGGGAGAAGCGCTGCGAGCCATGC
CGAATGTCGGTCTCGATAGCGACTTCGAGCGGATCAACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References