Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 362245..362888 Replicon chromosome
Accession NZ_CP095021
Organism Mycobacterium tuberculosis strain SGF0422017

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag MUW66_RS01580 Protein ID WP_003401566.1
Coordinates 362463..362888 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag MUW66_RS01575 Protein ID WP_003401563.1
Coordinates 362245..362466 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW66_RS01550 (MUW66_01550) 357364..358167 - 804 WP_003401540.1 Stf0 family sulphotransferase -
MUW66_RS01555 (MUW66_01555) 358177..359574 - 1398 WP_003401544.1 sulfatase -
MUW66_RS01560 (MUW66_01560) 359753..361528 + 1776 WP_010886074.1 PE family protein -
MUW66_RS01565 (MUW66_01565) 361671..361898 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
MUW66_RS01570 (MUW66_01570) 361895..362197 + 303 WP_003401560.1 toxin-antitoxin system toxin -
MUW66_RS01575 (MUW66_01575) 362245..362466 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
MUW66_RS01580 (MUW66_01580) 362463..362888 + 426 WP_003401566.1 PIN domain nuclease Toxin
MUW66_RS01585 (MUW66_01585) 363024..363656 + 633 WP_003905275.1 TetR/AcrR family transcriptional regulator -
MUW66_RS01590 (MUW66_01590) 363653..364561 + 909 WP_003900117.1 protochlorophyllide reductase -
MUW66_RS01595 (MUW66_01595) 364569..365159 - 591 WP_229298012.1 hypothetical protein -
MUW66_RS01600 (MUW66_01600) 365152..365202 - 51 Protein_316 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T241013 WP_003401566.1 NZ_CP095021:362463-362888 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T241013 NZ_LT906434:1831632-1831889 [Neisseria zoodegmatis]
ATGATCTTGGCTTGGGCAGATACTGCTTGGGAAGATTATCTCTATTGGCAAGCGGTAGATAAAAAGAATTTGAAGCGCAT
CAATTTGTTAATCAAAGATATTCAGCGTAATCCGTTTACAGGCGTGGGCAATCCTGAGCCGTTAAAACATAACTGGCAGG
GTTTTTGGTCTCGGCGTATTGATCTAGAACATCGGTTGGTTTATCAGATACGCGATGAAATGTTGTTTATTGCTCAATGC
CGCTACCATTATTCGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT241013 WP_003401563.1 NZ_CP095021:362245-362466 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT241013 NZ_LT906434:1831381-1831635 [Neisseria zoodegmatis]
ATGGATGTAATGAGCTATACCGCTTTTCGTGCCGAGCTTGCGGGAACCTTAGACAAGGTTGTAGAAAACCACAAACCCGT
TTTGATTACCCGACAAAACGGCAAGCCCGCCGTAGTCATGAGCTTGGAAGATTTTCATGCGTATGAAGAAACGGCTTATT
TGACAGCAAGTCCTAAAAATGCCGAACGGTTAAACCGTGCTGTTGAACAAATCCGTCAAAACCAAGCAATCCGCCATGAA
TTGATTGAATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References