Detailed information of TA system TA024101

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2426251..2427176
• Replicon: chromosome
• Accession: NC_012962
• Organism: Photorhabdus asymbiotica

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: PAU_RS10430
• Protein ID: WP_015834298.1
• Coordinates: 2426251..2426730 (-)
• Length: 160 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: PAU_RS10435
• Protein ID: WP_015834299.1
• Coordinates: 2426727..2427176 (-)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PAU_RS10410	2422421..2423593	-	1173	WP_015834293.1	mannose-6-phosphate isomerase	-
PAU_RS10415	2423997..2425391	+	1395	WP_015834295.1	class II fumarate hydratase	-
PAU_RS10420	2425533..2425811	+	279	WP_015834296.1	type II toxin-antitoxin system RelE/ParE family toxin	-
PAU_RS10425	2425811..2426125	+	315	WP_015834297.1	HigA family addiction module antidote protein	-
PAU_RS10430	2426251..2426730	-	480	WP_015834298.1	RES family NAD+ phosphorylase	Toxin
PAU_RS10435	2426727..2427176	-	450	WP_015834299.1	type II toxin-antitoxin system antitoxin Xre	Antitoxin
PAU_RS10440	2427441..2428010	+	570	WP_015834300.1	hypothetical protein	-
PAU_RS10445	2428147..2428518	+	372	WP_015834301.1	VOC family protein	-
PAU_RS10450	2428799..2429725	-	927	WP_015834303.1	DNA replication terminus site-binding protein	-
PAU_RS10455	2429955..2431109	+	1155	WP_015834304.1	radical SAM protein	-
PAU_RS10460	2431120..2431710	+	591	WP_158307062.1	LysE family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre (16-149)

Sequences

Toxin

Protein

• Length: 160 a.a.
• Molecular weight: 17819.43 Da
• Isoelectric Point: 4.9036

>T24101 WP_015834298.1 NC_012962:c2426730-2426251 [Photorhabdus asymbiotica]
VILYRLTRSKYVESAWSGTGAKLYGGRWHNIGRPAVYVATSISLAVLEVLVHVGDDELLADFSLLSIDIPENQIDILNLD
TLPPDWNDPIPPACTMEIGSEWFEVSHSIGLMVPSAIVPYENNVMLNPMAKDFHQYINTVKHLDFGIDSRLVKTKNNLR

Nucleotide

• Length: 480 bp

>T24101 NC_012962:c2426730-2426251 [Photorhabdus asymbiotica]
GTGATCCTATACCGACTTACCCGTTCAAAGTATGTCGAATCAGCATGGAGCGGTACTGGGGCAAAACTGTATGGTGGCCG
CTGGCATAATATAGGAAGACCAGCGGTCTATGTTGCCACTTCTATTTCTCTTGCTGTGCTGGAAGTACTTGTCCATGTAG
GAGACGATGAGCTTCTCGCTGATTTTTCGCTGTTAAGTATCGATATCCCCGAAAACCAAATTGATATTTTAAACCTTGAT
ACATTACCGCCTGATTGGAATGATCCCATACCTCCTGCTTGCACTATGGAAATAGGCAGTGAATGGTTCGAAGTTAGTCA
TTCCATTGGTCTGATGGTTCCCTCTGCCATCGTCCCTTATGAAAATAACGTCATGTTGAACCCCATGGCGAAAGATTTTC
ATCAGTATATCAATACAGTTAAACACCTTGATTTCGGCATTGATTCCCGATTGGTAAAGACAAAAAATAATCTGAGATAG

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16618.06 Da
• Isoelectric Point: 10.5114

>AT24101 WP_015834299.1 NC_012962:c2427176-2426727 [Photorhabdus asymbiotica]
MQVFTPSHKVQSPSPLWRTVGFPSSSGPHLNAVLNEGLPVTIVEKIQNWSTFGKGDILRIAGIQIRSYSRRRSGKGKFTA
DESQRIARFVRVMDYAVDLFNGDKDKATQWMKRPIRGLGYVTPESMLDTESGALDVMNLIGRIEHGIVS

Nucleotide

• Length: 450 bp

>AT24101 NC_012962:c2427176-2426727 [Photorhabdus asymbiotica]
ATGCAAGTTTTTACACCAAGCCATAAAGTCCAAAGTCCTTCCCCACTTTGGCGAACAGTGGGTTTCCCTTCAAGCAGCGG
GCCACATTTGAATGCGGTATTAAACGAAGGGCTACCAGTAACGATAGTTGAGAAAATACAAAATTGGTCCACATTCGGTA
AAGGAGATATCCTGCGGATTGCTGGTATTCAAATACGCAGCTATTCAAGACGCCGTTCAGGCAAAGGTAAATTCACGGCT
GATGAAAGTCAGCGGATTGCCCGATTCGTTCGTGTAATGGATTACGCTGTGGATCTATTTAACGGTGACAAAGATAAAGC
AACTCAGTGGATGAAGCGCCCAATCCGAGGTTTAGGATACGTAACACCTGAATCAATGCTTGATACAGAAAGTGGAGCGT
TAGATGTCATGAATCTCATAGGAAGAATTGAGCACGGGATTGTATCGTGA