Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3700399..3701073 Replicon chromosome
Accession NZ_CP095020
Organism Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag MUW65_RS17520 Protein ID WP_003417282.1
Coordinates 3700399..3700827 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag MUW65_RS17525 Protein ID WP_003417286.1
Coordinates 3700831..3701073 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW65_RS17495 (MUW65_17495) 3696221..3696622 - 402 WP_003417264.1 cytidine deaminase -
MUW65_RS17500 (MUW65_17500) 3696859..3697197 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
MUW65_RS17505 (MUW65_17505) 3697194..3697628 + 435 WP_003902441.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
MUW65_RS17510 (MUW65_17510) 3697757..3699529 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
MUW65_RS17515 (MUW65_17515) 3699529..3700320 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
MUW65_RS17520 (MUW65_17520) 3700399..3700827 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW65_RS17525 (MUW65_17525) 3700831..3701073 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
MUW65_RS17530 (MUW65_17530) 3701195..3701809 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
MUW65_RS17535 (MUW65_17535) 3701806..3702471 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
MUW65_RS17540 (MUW65_17540) 3702472..3703005 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
MUW65_RS17545 (MUW65_17545) 3703002..3703376 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
MUW65_RS17550 (MUW65_17550) 3703473..3704609 - 1137 WP_003417297.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T241006 WP_003417282.1 NZ_CP095020:c3700827-3700399 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T241006 NZ_LT905060:c4139362-4138874 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATCTCCGCCCCTGAACCGCTTCATGCCGGGCATATTCTTACCCCCTTCTGCTGCGGTGTGGATTCAATGGATAACTG
GCTAAAACAGCGGGCGATGAAAAATCAGGTAACTGGCGCATCCCGTACCTTTGTGTGTTGCGGCAGCGATTCTGACGTAC
TGGCGTATTATTCGCTGGCGTCCAGCGCGGTAACGACAAACACCGCCCCCGGTCGCTTTCGTCGCAATATGCCCGATCCG
ATCCCGGTTGTGGTGCTGGGCCGTCTGGCGGTGGATCGGTCGCTACATGGGCAGGGCGTAGGTCGGGCGCTGGTGAGGGA
TGCCGGGCTGCGGGTGATTCAGGTGGCGGAAACTATCGGTATTCGCGGGATGCTGGTCCATGCCCTGTCGGATGAAGCGC
GGGAGTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTT
CATGCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT241006 WP_003417286.1 NZ_CP095020:c3701073-3700831 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT241006 NZ_LT905060:c4139652-4139359 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCCAGTCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGCATCAAGCCCGCCGAGCGCGATCTTATCGA
TCGGGCTGCAAAAGCCAGAGGGAAAAACTGCACAGACTTTGTGCTAGAAGCTGCCCGCGCCGCCGCCGAGGAAGCGCTGA
TCGAGCAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGCATTTCTGATCCGTCTGGATCAGGCTCCTGCGCCAAAC
GATGCGTTGCGTAAAACCATGCAGACTCCTGCACCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References