Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3166167..3166715 Replicon chromosome
Accession NZ_CP095020
Organism Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag MUW65_RS15105 Protein ID WP_003414602.1
Coordinates 3166452..3166715 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag MUW65_RS15100 Protein ID WP_003414599.1
Coordinates 3166167..3166448 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW65_RS15075 (MUW65_15075) 3161791..3162648 - 858 WP_003899513.1 type I methionyl aminopeptidase -
MUW65_RS15080 (MUW65_15080) 3162690..3163274 - 585 WP_003414585.1 DUF1707 domain-containing protein -
MUW65_RS15085 (MUW65_15085) 3163377..3163625 + 249 WP_003913411.1 antitoxin VapB23 -
MUW65_RS15090 (MUW65_15090) 3163622..3164002 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
MUW65_RS15095 (MUW65_15095) 3164084..3165895 - 1812 WP_003414596.1 penicillin-binding protein -
MUW65_RS15100 (MUW65_15100) 3166167..3166448 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
MUW65_RS15105 (MUW65_15105) 3166452..3166715 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MUW65_RS15110 (MUW65_15110) 3167088..3167942 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
MUW65_RS15115 (MUW65_15115) 3167998..3169161 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
MUW65_RS15120 (MUW65_15120) 3169178..3170392 - 1215 WP_003414610.1 zinc metalloprotease Rip -
MUW65_RS15125 (MUW65_15125) 3170400..3171641 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T241003 WP_003414602.1 NZ_CP095020:3166452-3166715 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T241003 NZ_LT905060:c2761845-2761743 [Salmonella enterica subsp. enterica serovar Typhi]
GCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT241003 WP_003414599.1 NZ_CP095020:3166167-3166448 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT241003 NZ_LT905060:2761741-2761884 [Salmonella enterica subsp. enterica serovar Typhi]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References