Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 3125241..3125845 Replicon chromosome
Accession NZ_CP095020
Organism Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag MUW65_RS14910 Protein ID WP_003414492.1
Coordinates 3125241..3125633 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A829CBY8
Locus tag MUW65_RS14915 Protein ID WP_003414495.1
Coordinates 3125630..3125845 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW65_RS14880 (MUW65_14880) 3120391..3121179 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
MUW65_RS14885 (MUW65_14885) 3121513..3122058 - 546 WP_014584866.1 DUF1802 family protein -
MUW65_RS14890 (MUW65_14890) 3122330..3123214 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
MUW65_RS14895 (MUW65_14895) 3123217..3124104 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin -
MUW65_RS14900 (MUW65_14900) 3124409..3124954 - 546 WP_003910939.1 DUF1802 family protein -
MUW65_RS14905 (MUW65_14905) 3124951..3125220 - 270 WP_003414489.1 DUF2277 family protein -
MUW65_RS14910 (MUW65_14910) 3125241..3125633 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW65_RS14915 (MUW65_14915) 3125630..3125845 - 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUW65_RS14920 (MUW65_14920) 3125892..3126641 + 750 WP_003902358.1 enoyl-CoA hydratase -
MUW65_RS14925 (MUW65_14925) 3126720..3127802 - 1083 WP_003414499.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -
MUW65_RS14930 (MUW65_14930) 3127795..3129105 - 1311 WP_003414501.1 ABC transporter substrate-binding protein -
MUW65_RS14935 (MUW65_14935) 3129108..3129935 - 828 WP_003414504.1 carbohydrate ABC transporter permease -
MUW65_RS14940 (MUW65_14940) 3129932..3130843 - 912 WP_003414505.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T241002 WP_003414492.1 NZ_CP095020:c3125633-3125241 [Mycobacterium tuberculosis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T241002 NZ_LT905060:c1396203-1395985 [Salmonella enterica subsp. enterica serovar Typhi]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7511.55 Da        Isoelectric Point: 4.9732

>AT241002 WP_003414495.1 NZ_CP095020:c3125845-3125630 [Mycobacterium tuberculosis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Download         Length: 216 bp

>AT241002 NZ_LT905060:c1396605-1396231 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBY8

References