Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2924696..2925410 Replicon chromosome
Accession NZ_CP095020
Organism Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag MUW65_RS13720 Protein ID WP_003413460.1
Coordinates 2924970..2925410 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag MUW65_RS13715 Protein ID WP_003413456.1
Coordinates 2924696..2924983 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW65_RS13680 (MUW65_13680) 2920118..2920363 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
MUW65_RS13685 (MUW65_13685) 2920360..2920764 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
MUW65_RS13690 (MUW65_13690) 2920981..2921601 + 621 WP_003413441.1 DUF4178 domain-containing protein -
MUW65_RS13695 (MUW65_13695) 2921612..2922106 + 495 WP_003413444.1 DUF2617 family protein -
MUW65_RS13700 (MUW65_13700) 2922103..2922534 + 432 WP_003899390.1 DUF4247 domain-containing protein -
MUW65_RS13705 (MUW65_13705) 2922559..2923017 + 459 WP_003413451.1 DUF350 domain-containing protein -
MUW65_RS13710 (MUW65_13710) 2923014..2924585 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
MUW65_RS13715 (MUW65_13715) 2924696..2924983 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
MUW65_RS13720 (MUW65_13720) 2924970..2925410 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW65_RS13725 (MUW65_13725) 2925431..2926186 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
MUW65_RS13730 (MUW65_13730) 2926319..2926915 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
MUW65_RS13735 (MUW65_13735) 2926923..2927768 - 846 WP_003413466.1 acyl-CoA thioesterase II -
MUW65_RS13740 (MUW65_13740) 2927797..2928696 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
MUW65_RS13745 (MUW65_13745) 2928824..2929498 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T240996 WP_003413460.1 NZ_CP095020:2924970-2925410 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T240996 NZ_LT903847:4351705-4351923 [Escherichia coli O127:H6]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT240996 WP_003413456.1 NZ_CP095020:2924696-2924983 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT240996 NZ_LT903847:4351305-4351679 [Escherichia coli O127:H6]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References