Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2848899..2849539 Replicon chromosome
Accession NZ_CP095020
Organism Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ08
Locus tag MUW65_RS13345 Protein ID WP_003412970.1
Coordinates 2848899..2849318 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ09
Locus tag MUW65_RS13350 Protein ID WP_003412975.1
Coordinates 2849315..2849539 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW65_RS13315 (MUW65_13315) 2844489..2845211 - 723 WP_003412957.1 DUF1906 domain-containing protein -
MUW65_RS13320 (MUW65_13320) 2845728..2845950 + 223 Protein_2631 type II toxin-antitoxin system VapB family antitoxin -
MUW65_RS13325 (MUW65_13325) 2845947..2846348 + 402 WP_003412963.1 PIN domain-containing protein -
MUW65_RS13330 (MUW65_13330) 2846383..2847303 - 921 WP_003412965.1 restriction endonuclease -
MUW65_RS13335 (MUW65_13335) 2847644..2847889 - 246 WP_071854223.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
MUW65_RS13340 (MUW65_13340) 2847948..2848898 + 951 WP_003911916.1 ERCC4 domain-containing protein -
MUW65_RS13345 (MUW65_13345) 2848899..2849318 - 420 WP_003412970.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW65_RS13350 (MUW65_13350) 2849315..2849539 - 225 WP_003412975.1 antitoxin VapB39 Antitoxin
MUW65_RS13355 (MUW65_13355) 2849570..2852413 - 2844 WP_003899363.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
MUW65_RS13360 (MUW65_13360) 2852485..2852886 - 402 WP_003412981.1 hypothetical protein -
MUW65_RS13365 (MUW65_13365) 2852886..2853356 - 471 WP_003899364.1 transcription antitermination factor NusB -
MUW65_RS13370 (MUW65_13370) 2853359..2853922 - 564 WP_003412989.1 elongation factor P -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14732.70 Da        Isoelectric Point: 6.7519

>T240992 WP_003412970.1 NZ_CP095020:c2849318-2848899 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Download         Length: 420 bp

>T240992 NZ_LT903847:3477855-3477962 [Escherichia coli O127:H6]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7993.94 Da        Isoelectric Point: 4.0057

>AT240992 WP_003412975.1 NZ_CP095020:c2849539-2849315 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Download         Length: 225 bp

>AT240992 NZ_LT903847:c3477805-3477742 [Escherichia coli O127:H6]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ08

Antitoxin

Source ID Structure
AlphaFold DB G0TQ09

References