Detailed information of TA system TA240989

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2362907..2363602
• Replicon: chromosome
• Accession: NZ_CP095020
• Organism: Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MUW65_RS11040
• Protein ID: WP_003905754.1
• Coordinates: 2362907..2363341 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TMN0
• Locus tag: MUW65_RS11045
• Protein ID: WP_003410814.1
• Coordinates: 2363348..2363602 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUW65_RS11030 (MUW65_11030)	2359061..2362102	+	3042	WP_003899171.1	DEAD/DEAH box helicase	-
MUW65_RS11035 (MUW65_11035)	2362095..2362928	+	834	WP_003899172.1	SWIM zinc finger family protein	-
MUW65_RS11040 (MUW65_11040)	2362907..2363341	-	435	WP_003905754.1	type II toxin-antitoxin system VapC family toxin	Toxin
MUW65_RS11045 (MUW65_11045)	2363348..2363602	-	255	WP_003410814.1	antitoxin	Antitoxin
MUW65_RS11050 (MUW65_11050)	2363618..2363875	-	258	WP_003410816.1	hypothetical protein	-
MUW65_RS11055 (MUW65_11055)	2364409..2365670	+	1262	WP_087902221.1	IS3-like element IS987 family transposase	-
MUW65_RS11060 (MUW65_11060)	2366180..2366476	+	297	WP_003410820.1	PE family protein	-
MUW65_RS11065 (MUW65_11065)	2366532..2367263	+	732	WP_003900467.1	PPE family protein	-
MUW65_RS11070 (MUW65_11070)	2367803..2368549	-	747	WP_003901330.1	proteasome subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15632.05 Da
• Isoelectric Point: 7.4681

>T240989 WP_003905754.1 NZ_CP095020:c2363341-2362907 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Nucleotide

• Length: 435 bp

>T240989 NZ_LT903847:2840007-2840109 [Escherichia coli O127:H6]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9417.57 Da
• Isoelectric Point: 8.9912

>AT240989 WP_003410814.1 NZ_CP095020:c2363602-2363348 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Nucleotide

• Length: 255 bp

>AT240989 NZ_LT903847:c2840147-2839879 [Escherichia coli O127:H6]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGGGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Structures

Antitoxin

• AlphaFold DB: G0TMN0