Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2225126..2226024 Replicon chromosome
Accession NZ_CP095020
Organism Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag MUW65_RS10420 Protein ID WP_003410001.1
Coordinates 2225126..2225686 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag MUW65_RS10425 Protein ID WP_003410003.1
Coordinates 2225683..2226024 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW65_RS10390 (MUW65_10390) 2220295..2220948 - 654 WP_244702835.1 cutinase Cfp21 -
MUW65_RS10395 (MUW65_10395) 2221063..2221293 + 231 WP_003409980.1 DUF167 domain-containing protein -
MUW65_RS10400 (MUW65_10400) 2221378..2222289 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
MUW65_RS10405 (MUW65_10405) 2222398..2222997 + 600 WP_003910883.1 L-lysine exporter -
MUW65_RS10410 (MUW65_10410) 2223413..2223841 + 429 WP_003409992.1 cellulose-binding protein -
MUW65_RS10415 (MUW65_10415) 2224067..2224606 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
MUW65_RS10420 (MUW65_10420) 2225126..2225686 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
MUW65_RS10425 (MUW65_10425) 2225683..2226024 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
MUW65_RS10430 (MUW65_10430) 2226110..2226367 + 258 WP_003410006.1 hypothetical protein -
MUW65_RS10435 (MUW65_10435) 2226268..2226603 - 336 WP_003410009.1 dehydrogenase -
MUW65_RS10440 (MUW65_10440) 2226692..2227036 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
MUW65_RS10445 (MUW65_10445) 2227030..2227278 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
MUW65_RS10450 (MUW65_10450) 2227378..2229693 - 2316 WP_003899120.1 cation transporter ATPase CptG -
MUW65_RS10455 (MUW65_10455) 2229690..2229962 - 273 WP_003410017.1 DUF1490 family protein -
MUW65_RS10460 (MUW65_10460) 2230015..2230371 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T240984 WP_003410001.1 NZ_CP095020:c2225686-2225126 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T240984 NZ_LT903847:1620916-1621323 [Escherichia coli O127:H6]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT240984 WP_003410003.1 NZ_CP095020:c2226024-2225683 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT240984 NZ_LT903847:1620669-1620935 [Escherichia coli O127:H6]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References