Detailed information of TA system TA240982

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 2191572..2192116
• Replicon: chromosome
• Accession: NZ_CP095020
• Organism: Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0TLU9
• Locus tag: MUW65_RS10225
• Protein ID: WP_003409896.1
• Coordinates: 2191572..2191868 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P67299
• Locus tag: MUW65_RS10230
• Protein ID: WP_003409899.1
• Coordinates: 2191865..2192116 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUW65_RS10170 (MUW65_10170)	2186605..2186955	-	351	WP_003409871.1	hypothetical protein	-
MUW65_RS10175 (MUW65_10175)	2186966..2187868	-	903	WP_003899097.1	hypothetical protein	-
MUW65_RS10180 (MUW65_10180)	2187889..2188080	-	192	WP_003409876.1	hypothetical protein	-
MUW65_RS10185 (MUW65_10185)	2188081..2188377	-	297	WP_003409877.1	hypothetical protein	-
MUW65_RS10190 (MUW65_10190)	2188617..2188832	+	216	WP_003409878.1	antitoxin	-
MUW65_RS10195 (MUW65_10195)	2188829..2189140	+	312	WP_003409881.1	type II toxin-antitoxin system VapC family toxin	-
MUW65_RS10200 (MUW65_10200)	2189114..2189635	-	522	WP_003904745.1	hypothetical protein	-
MUW65_RS10205 (MUW65_10205)	2189610..2189987	+	378	WP_010886136.1	type II toxin-antitoxin system toxin HigB	-
MUW65_RS10210 (MUW65_10210)	2190029..2190478	+	450	WP_003409886.1	type II toxin-antitoxin system antitoxin HigA	-
MUW65_RS10215 (MUW65_10215)	2190475..2191020	+	546	WP_003409891.1	SecB-like chaperone	-
MUW65_RS10220 (MUW65_10220)	2190909..2191523	-	615	WP_003901296.1	hypothetical protein	-
MUW65_RS10225 (MUW65_10225)	2191572..2191868	-	297	WP_003409896.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MUW65_RS10230 (MUW65_10230)	2191865..2192116	-	252	WP_003409899.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
MUW65_RS10235 (MUW65_10235)	2192103..2192597	+	495	WP_003899099.1	hypothetical protein	-
MUW65_RS10240 (MUW65_10240)	2192757..2193164	-	408	WP_003409913.1	type II toxin-antitoxin system VapC family toxin	-
MUW65_RS10245 (MUW65_10245)	2193168..2193440	-	273	WP_003899100.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
MUW65_RS10250 (MUW65_10250)	2193473..2194693	-	1221	WP_003409919.1	TetR family transcriptional regulator Mce3R	-
MUW65_RS10255 (MUW65_10255)	2195592..2196389	+	798	WP_003899101.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-93)

Antitoxin

• Antitoxin ParD (2-80)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11268.64 Da
• Isoelectric Point: 6.8604

>T240982 WP_003409896.1 NZ_CP095020:c2191868-2191572 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Nucleotide

• Length: 297 bp

>T240982 NZ_LT903847:1014683-1014790 [Escherichia coli O127:H6]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9207.17 Da
• Isoelectric Point: 7.0150

>AT240982 WP_003409899.1 NZ_CP095020:c2192116-2191865 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Nucleotide

• Length: 252 bp

>AT240982 NZ_LT903847:c1014635-1014569 [Escherichia coli O127:H6]
GGTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: G0TLU9

Antitoxin

• AlphaFold DB: A0A7U4BUZ2