Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1961984..1962444 Replicon chromosome
Accession NZ_CP095020
Organism Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag MUW65_RS09160 Protein ID WP_003898996.1
Coordinates 1962196..1962444 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag MUW65_RS09155 Protein ID WP_003408528.1
Coordinates 1961984..1962196 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW65_RS09140 (MUW65_09140) 1958462..1959649 - 1188 WP_003898992.1 nitrate transporter NarK -
MUW65_RS09145 (MUW65_09145) 1959936..1960220 + 285 WP_003408522.1 DUF1876 domain-containing protein -
MUW65_RS09150 (MUW65_09150) 1960234..1961916 - 1683 WP_003901239.1 SulP family inorganic anion transporter -
MUW65_RS09155 (MUW65_09155) 1961984..1962196 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MUW65_RS09160 (MUW65_09160) 1962196..1962444 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW65_RS09165 (MUW65_09165) 1962452..1963189 + 738 WP_003898997.1 hypothetical protein -
MUW65_RS09170 (MUW65_09170) 1963283..1964983 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
MUW65_RS09175 (MUW65_09175) 1965268..1965669 - 402 WP_003408538.1 hypothetical protein -
MUW65_RS09180 (MUW65_09180) 1965659..1966270 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T240979 WP_003898996.1 NZ_CP095020:1962196-1962444 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T240979 NZ_LT903847:c264506-264333 [Escherichia coli O127:H6]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTTTACCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT240979 WP_003408528.1 NZ_CP095020:1961984-1962196 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT240979 NZ_LT903847:c264830-264534 [Escherichia coli O127:H6]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References