Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1941160..1941773 Replicon chromosome
Accession NZ_CP095020
Organism Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag MUW65_RS09045 Protein ID WP_003408465.1
Coordinates 1941160..1941549 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag MUW65_RS09050 Protein ID WP_003408469.1
Coordinates 1941546..1941773 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW65_RS09010 (MUW65_09010) 1936789..1937703 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
MUW65_RS09015 (MUW65_09015) 1937706..1938536 + 831 WP_003408448.1 cyclase family protein -
MUW65_RS09020 (MUW65_09020) 1938536..1938886 + 351 WP_003898986.1 cupin domain-containing protein -
MUW65_RS09025 (MUW65_09025) 1938939..1939757 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
MUW65_RS09030 (MUW65_09030) 1939771..1940550 + 780 WP_003408460.1 IclR family transcriptional regulator -
MUW65_RS09040 (MUW65_09040) 1940981..1941112 + 132 Protein_1782 IS3 family transposase -
MUW65_RS09045 (MUW65_09045) 1941160..1941549 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW65_RS09050 (MUW65_09050) 1941546..1941773 - 228 WP_003408469.1 antitoxin Antitoxin
MUW65_RS09055 (MUW65_09055) 1941991..1943475 + 1485 WP_003408473.1 biotin carboxylase -
MUW65_RS09060 (MUW65_09060) 1943472..1944719 + 1248 WP_003408476.1 serine hydrolase -
MUW65_RS09065 (MUW65_09065) 1944762..1945181 - 420 WP_003408483.1 hypothetical protein -
MUW65_RS09070 (MUW65_09070) 1945171..1945881 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T240978 WP_003408465.1 NZ_CP095020:c1941549-1941160 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T240978 NZ_LT900343:1641-1964 [Gluconobacter oxydans 621H]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT240978 WP_003408469.1 NZ_CP095020:c1941773-1941546 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT240978 NZ_LT900343:1426-1644 [Gluconobacter oxydans 621H]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References