Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1689618..1690234 Replicon chromosome
Accession NZ_CP095020
Organism Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag MUW65_RS07950 Protein ID WP_003407593.1
Coordinates 1689917..1690234 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag MUW65_RS07945 Protein ID WP_003900349.1
Coordinates 1689618..1689920 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW65_RS07935 (MUW65_07935) 1685504..1687351 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
MUW65_RS07940 (MUW65_07940) 1687352..1689604 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
MUW65_RS07945 (MUW65_07945) 1689618..1689920 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
MUW65_RS07950 (MUW65_07950) 1689917..1690234 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
MUW65_RS07955 (MUW65_07955) 1690231..1691235 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
MUW65_RS07960 (MUW65_07960) 1691288..1692577 + 1290 WP_003902090.1 serine hydrolase domain-containing protein -
MUW65_RS07965 (MUW65_07965) 1692650..1693375 - 726 WP_003898898.1 class I SAM-dependent methyltransferase -
MUW65_RS07970 (MUW65_07970) 1693481..1693693 - 213 WP_003898900.1 dodecin family protein -
MUW65_RS07975 (MUW65_07975) 1693754..1694152 + 399 WP_003900351.1 hypothetical protein -
MUW65_RS07980 (MUW65_07980) 1694197..1695225 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T240976 WP_003407593.1 NZ_CP095020:1689917-1690234 [Mycobacterium tuberculosis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T240976 NZ_LT900341:13942-14217 [Gluconobacter oxydans 621H]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT240976 WP_003900349.1 NZ_CP095020:1689618-1689920 [Mycobacterium tuberculosis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT240976 NZ_LT900341:14214-14483 [Gluconobacter oxydans 621H]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References