Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1575736..1576391 Replicon chromosome
Accession NZ_CP095020
Organism Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag MUW65_RS07445 Protein ID WP_003898861.1
Coordinates 1575736..1576137 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag MUW65_RS07450 Protein ID WP_003407272.1
Coordinates 1576134..1576391 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW65_RS07430 (MUW65_07430) 1571208..1572593 - 1386 WP_003407260.1 cytochrome P450 -
MUW65_RS07435 (MUW65_07435) 1572671..1573705 + 1035 WP_003407264.1 AraC family transcriptional regulator -
MUW65_RS07440 (MUW65_07440) 1573751..1575481 - 1731 WP_009940170.1 PE family protein -
MUW65_RS07445 (MUW65_07445) 1575736..1576137 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW65_RS07450 (MUW65_07450) 1576134..1576391 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
MUW65_RS07455 (MUW65_07455) 1576474..1577433 - 960 WP_003407276.1 alpha/beta hydrolase -
MUW65_RS07460 (MUW65_07460) 1577458..1578420 - 963 WP_003905554.1 alpha/beta hydrolase -
MUW65_RS07465 (MUW65_07465) 1578419..1579156 + 738 WP_031647000.1 lysoplasmalogenase -
MUW65_RS07470 (MUW65_07470) 1579237..1581204 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T240975 WP_003898861.1 NZ_CP095020:c1576137-1575736 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T240975 NZ_LT900341:394-816 [Gluconobacter oxydans 621H]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9425.55 Da        Isoelectric Point: 6.4631

>AT240975 WP_003407272.1 NZ_CP095020:c1576391-1576134 [Mycobacterium tuberculosis]
IKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT240975 NZ_LT900341:146-397 [Gluconobacter oxydans 621H]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References