Detailed information of TA system TA240973

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1388720..1389279
• Replicon: chromosome
• Accession: NZ_CP095020
• Organism: Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: MUW65_RS06625
• Protein ID: WP_003898789.1
• Coordinates: 1388720..1389013 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: MUW65_RS06630
• Protein ID: WP_003406322.1
• Coordinates: 1389010..1389279 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUW65_RS06600 (MUW65_06600)	1384418..1384678	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
MUW65_RS06605 (MUW65_06605)	1384675..1385106	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
MUW65_RS06610 (MUW65_06610)	1385129..1386712	-	1584	WP_009940130.1	PE family protein	-
MUW65_RS06615 (MUW65_06615)	1386892..1387752	+	861	WP_003900301.1	glycine betaine ABC transporter substrate-binding protein	-
MUW65_RS06620 (MUW65_06620)	1387833..1388663	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
MUW65_RS06625 (MUW65_06625)	1388720..1389013	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
MUW65_RS06630 (MUW65_06630)	1389010..1389279	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MUW65_RS06635 (MUW65_06635)	1389392..1393087	-	3696	WP_003406323.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
MUW65_RS06640 (MUW65_06640)	1393229..1394017	-	789	WP_003406325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T240973 WP_003898789.1 NZ_CP095020:c1389013-1388720 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T240973 NZ_LT900217:3008276-3008569 [Gordonibacter urolithinfaciens]
ATGTATGCAGTGAAGTTCACGAAGCAGGCTGCAAAGGATGCAAAGAAGCTTAAAGCCGCTGGTCTCGACAAGAAGGCGAA
AGCACTTGTCGAGGTGCTTAAGAATGATCCCTTTCAAGAGGCTCCTGCCTACGAAACGCTTGTGGGGAACCTCTCGGGCC
TCTATTCGCGGCGCATCAACCTGCAGCATCGGCTCGTTTATCAGGTATATGCAGAGCCCTTTGCCGAGGGTGGCGAGGAA
TTCGATGGCACGGTCAAAGTCGTGCGCATGTGGACCCATTACGAGGGACTCTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT240973 WP_003406322.1 NZ_CP095020:c1389279-1389010 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT240973 NZ_LT900217:3008022-3008273 [Gordonibacter urolithinfaciens]
ATGACTTCGATCACTGCAACGGCTTTGCGGCAGAATATCTACCAGACCATCGCCCAGGTGAACGAGAACTGCACGCCCAT
CGCCATCACGAACAGCAAGGGGAAGGGGGCAGTGCTTATCGGCGAATCCGATTGGGCGGCTATCGAGGAAACGCTTTTCC
TCAACGGCATTCCCGGCATGAGCGAATCGCTGCGGGCCGGCATGGCGGAAAAACCCGAGGACTGCCTTTCTGAAGACCGA
CTTGAGTGGTAG

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2