Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1229503..1230134 Replicon chromosome
Accession NZ_CP095020
Organism Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag MUW65_RS05880 Protein ID WP_003405820.1
Coordinates 1229503..1229814 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag MUW65_RS05885 Protein ID WP_003405836.1
Coordinates 1229814..1230134 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW65_RS05860 (MUW65_05860) 1224984..1226408 - 1425 WP_003405805.1 class II fumarate hydratase -
MUW65_RS05865 (MUW65_05865) 1226439..1227527 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
MUW65_RS05870 (MUW65_05870) 1227583..1228227 + 645 WP_003915494.1 DUF4245 domain-containing protein -
MUW65_RS05875 (MUW65_05875) 1228234..1229391 - 1158 WP_003898727.1 AI-2E family transporter -
MUW65_RS05880 (MUW65_05880) 1229503..1229814 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
MUW65_RS05885 (MUW65_05885) 1229814..1230134 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
MUW65_RS05890 (MUW65_05890) 1230144..1231680 + 1537 Protein_1159 carboxylesterase/lipase family protein -
MUW65_RS05895 (MUW65_05895) 1231687..1232799 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
MUW65_RS05900 (MUW65_05900) 1232809..1233066 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
MUW65_RS05905 (MUW65_05905) 1233056..1234303 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
MUW65_RS05910 (MUW65_05910) 1234300..1234938 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T240970 WP_003405820.1 NZ_CP095020:c1229814-1229503 [Mycobacterium tuberculosis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T240970 NZ_LT900021:c1750541-1750131 [Thermococcus henrietii]
ATGCATGGGGTCATAGACACTAACGTCCTCATCTACGACACCTTCGAGGACACGGAGTTCCACAAAAAGGCTGAGGAAAC
CCTCGAATCCCTCGACAGGTGGTACGTTCCGGCGATAGTCGTGCAGGAGTACGTGTGGTTCTTCAAAAACAACGGTTTTT
CAGCGAGAGAGGCCCTCGAAGCCCTGAAGGGGTACACAGAGGACCCGAGATTCAAGGGATTGAGTGAAGACCCCAGACTA
ATCGAAAGCGCCCTGGACTTAGTGGTGAGGGAAGAGCTCTCGCTCTCACGTTTCAACGATGCGGTAATTCTCCTCCACGC
CCTGGAGAAGGGAAGCCTCGTTACCTTCGACGTCAAGCTGAGAAACTTGGCAAAAAGAAAAGGGGTTGTTGTTCTCCCAG
AGGAGCTTTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT240970 WP_003405836.1 NZ_CP095020:c1230134-1229814 [Mycobacterium tuberculosis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT240970 NZ_LT900021:c1750756-1750526 [Thermococcus henrietii]
ATGAGCATCACGAAAGTAACCCGGAACTACCAGATAACGATTCCGGCCGAGATTAGGAAAGCCCTCGGCATAAGGGAGGG
TGAACTTCTCGAAGTCAGCATCGAGGGAGACAGGATAGTCCTTCGGAGGCTCAGAAGGGAAAGAAAGCGCCTGAAACTCG
GCAAGAACGTGACGCTCGGGGAGATAGAGAAGTCCATCGAGGAGGGCATGAGGGAATGCATGGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References