Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 1022953..1023926 | Replicon | chromosome |
Accession | NZ_CP095020 | ||
Organism | Mycobacterium tuberculosis strain SGF0232017 |
Toxin (Protein)
Gene name | tacT | Uniprot ID | O05911 |
Locus tag | MUW65_RS04860 | Protein ID | WP_003404756.1 |
Coordinates | 1023426..1023926 (+) | Length | 167 a.a. |
Antitoxin (Protein)
Gene name | tacA | Uniprot ID | G0TFR4 |
Locus tag | MUW65_RS04855 | Protein ID | WP_003404754.1 |
Coordinates | 1022953..1023429 (+) | Length | 159 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MUW65_RS04835 (MUW65_04835) | 1018800..1020071 | - | 1272 | WP_003404747.1 | PPE family protein | - |
MUW65_RS04840 (MUW65_04840) | 1020086..1020385 | - | 300 | WP_003404748.1 | PE family protein | - |
MUW65_RS04845 (MUW65_04845) | 1020829..1022610 | + | 1782 | WP_003404749.1 | BCCT family transporter | - |
MUW65_RS04850 (MUW65_04850) | 1022610..1022864 | + | 255 | WP_003898646.1 | hypothetical protein | - |
MUW65_RS04855 (MUW65_04855) | 1022953..1023429 | + | 477 | WP_003404754.1 | DUF1778 domain-containing protein | Antitoxin |
MUW65_RS04860 (MUW65_04860) | 1023426..1023926 | + | 501 | WP_003404756.1 | GNAT family N-acetyltransferase | Toxin |
MUW65_RS04870 (MUW65_04870) | 1024239..1025558 | - | 1320 | WP_003404757.1 | IS256-like element IS1554 family transposase | - |
MUW65_RS04875 (MUW65_04875) | 1025846..1026427 | + | 582 | WP_003404760.1 | IS607-like element IS1535 family transposase | - |
MUW65_RS04880 (MUW65_04880) | 1026427..1028079 | + | 1653 | WP_003905412.1 | IS607 family element RNA-guided endonuclease TnpB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 167 a.a. Molecular weight: 18048.55 Da Isoelectric Point: 7.8659
>T240969 WP_003404756.1 NZ_CP095020:1023426-1023926 [Mycobacterium tuberculosis]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD
Download Length: 501 bp
>T240969 NZ_LT900021:1690766-1691170 [Thermococcus henrietii]
ATGAAGCTCTTCATTGATACCAACCTTTTCGTTTACCTCCTGACCAAGACACCTGAAGACGAAAGAAAGATAATCGAGTT
CTATGCCAAACTGATTGAGAATCACGACCTCTACACGAGCCCGTTGGTTCTTGACGAGACAATTCACGTCGCAAAGAAGA
AGTACAGCGTCCCATACGAGCTCTCGATTGAGTTCATAGACGAGAAGGTTCTTCCCTACGTTGAAGTTCTCCCACTAACG
GTCTTCGATTATCTAACCGCCAGACAAATAATCATGAATTACAACCTCCGCCCCTCCGATGCCCTCCACGTTGCGGTTAT
AGAGAACAACGGCCTTCAGGCGATAGTTAGTGAGGATGAAGATTTTGACGTTCTCCCGCTCAAGCGGGTCTGGCTGGGTG
GTTGA
ATGAAGCTCTTCATTGATACCAACCTTTTCGTTTACCTCCTGACCAAGACACCTGAAGACGAAAGAAAGATAATCGAGTT
CTATGCCAAACTGATTGAGAATCACGACCTCTACACGAGCCCGTTGGTTCTTGACGAGACAATTCACGTCGCAAAGAAGA
AGTACAGCGTCCCATACGAGCTCTCGATTGAGTTCATAGACGAGAAGGTTCTTCCCTACGTTGAAGTTCTCCCACTAACG
GTCTTCGATTATCTAACCGCCAGACAAATAATCATGAATTACAACCTCCGCCCCTCCGATGCCCTCCACGTTGCGGTTAT
AGAGAACAACGGCCTTCAGGCGATAGTTAGTGAGGATGAAGATTTTGACGTTCTCCCGCTCAAGCGGGTCTGGCTGGGTG
GTTGA
Antitoxin
Download Length: 159 a.a. Molecular weight: 17357.95 Da Isoelectric Point: 11.2467
>AT240969 WP_003404754.1 NZ_CP095020:1022953-1023429 [Mycobacterium tuberculosis]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG
Download Length: 477 bp
>AT240969 NZ_LT900021:1690485-1690769 [Thermococcus henrietii]
GTGATACCTTTGGTTAGCATACGTCTCAAGGTCGGCCCCAAGGGACAGATTGTCATCCCCAAGGTTTTTCGCGAGGCCTA
CGGCATAAAGGAAGGGGGAGAGGTCATAGTTGAGCCTACAGATAAAGGACTGATAATCATGCCCAAGAAAAGCAAAGAGG
AGCTGATTAAAGAGCTCCTCGAATGGAAGCACAAGAGGGCCAGGGGCAAGCCTGCCAAGCTTGGAGAACTCAAGGGGATA
AGTCTCGAAGATGAGTTCGACGAGGTCTGGGGGATTGAGGAATGA
GTGATACCTTTGGTTAGCATACGTCTCAAGGTCGGCCCCAAGGGACAGATTGTCATCCCCAAGGTTTTTCGCGAGGCCTA
CGGCATAAAGGAAGGGGGAGAGGTCATAGTTGAGCCTACAGATAAAGGACTGATAATCATGCCCAAGAAAAGCAAAGAGG
AGCTGATTAAAGAGCTCCTCGAATGGAAGCACAAGAGGGCCAGGGGCAAGCCTGCCAAGCTTGGAGAACTCAAGGGGATA
AGTCTCGAAGATGAGTTCGACGAGGTCTGGGGGATTGAGGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BSZ2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TFR4 |