Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1022953..1023926 Replicon chromosome
Accession NZ_CP095020
Organism Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)


Gene name tacT Uniprot ID O05911
Locus tag MUW65_RS04860 Protein ID WP_003404756.1
Coordinates 1023426..1023926 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID G0TFR4
Locus tag MUW65_RS04855 Protein ID WP_003404754.1
Coordinates 1022953..1023429 (+) Length 159 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW65_RS04835 (MUW65_04835) 1018800..1020071 - 1272 WP_003404747.1 PPE family protein -
MUW65_RS04840 (MUW65_04840) 1020086..1020385 - 300 WP_003404748.1 PE family protein -
MUW65_RS04845 (MUW65_04845) 1020829..1022610 + 1782 WP_003404749.1 BCCT family transporter -
MUW65_RS04850 (MUW65_04850) 1022610..1022864 + 255 WP_003898646.1 hypothetical protein -
MUW65_RS04855 (MUW65_04855) 1022953..1023429 + 477 WP_003404754.1 DUF1778 domain-containing protein Antitoxin
MUW65_RS04860 (MUW65_04860) 1023426..1023926 + 501 WP_003404756.1 GNAT family N-acetyltransferase Toxin
MUW65_RS04870 (MUW65_04870) 1024239..1025558 - 1320 WP_003404757.1 IS256-like element IS1554 family transposase -
MUW65_RS04875 (MUW65_04875) 1025846..1026427 + 582 WP_003404760.1 IS607-like element IS1535 family transposase -
MUW65_RS04880 (MUW65_04880) 1026427..1028079 + 1653 WP_003905412.1 IS607 family element RNA-guided endonuclease TnpB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(38-143)

Antitoxin

(74-150)


Sequences


Toxin        


Download         Length: 167 a.a.        Molecular weight: 18048.55 Da        Isoelectric Point: 7.8659

>T240969 WP_003404756.1 NZ_CP095020:1023426-1023926 [Mycobacterium tuberculosis]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD

Download         Length: 501 bp

>T240969 NZ_LT900021:1690766-1691170 [Thermococcus henrietii]
ATGAAGCTCTTCATTGATACCAACCTTTTCGTTTACCTCCTGACCAAGACACCTGAAGACGAAAGAAAGATAATCGAGTT
CTATGCCAAACTGATTGAGAATCACGACCTCTACACGAGCCCGTTGGTTCTTGACGAGACAATTCACGTCGCAAAGAAGA
AGTACAGCGTCCCATACGAGCTCTCGATTGAGTTCATAGACGAGAAGGTTCTTCCCTACGTTGAAGTTCTCCCACTAACG
GTCTTCGATTATCTAACCGCCAGACAAATAATCATGAATTACAACCTCCGCCCCTCCGATGCCCTCCACGTTGCGGTTAT
AGAGAACAACGGCCTTCAGGCGATAGTTAGTGAGGATGAAGATTTTGACGTTCTCCCGCTCAAGCGGGTCTGGCTGGGTG
GTTGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 17357.95 Da        Isoelectric Point: 11.2467

>AT240969 WP_003404754.1 NZ_CP095020:1022953-1023429 [Mycobacterium tuberculosis]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG

Download         Length: 477 bp

>AT240969 NZ_LT900021:1690485-1690769 [Thermococcus henrietii]
GTGATACCTTTGGTTAGCATACGTCTCAAGGTCGGCCCCAAGGGACAGATTGTCATCCCCAAGGTTTTTCGCGAGGCCTA
CGGCATAAAGGAAGGGGGAGAGGTCATAGTTGAGCCTACAGATAAAGGACTGATAATCATGCCCAAGAAAAGCAAAGAGG
AGCTGATTAAAGAGCTCCTCGAATGGAAGCACAAGAGGGCCAGGGGCAAGCCTGCCAAGCTTGGAGAACTCAAGGGGATA
AGTCTCGAAGATGAGTTCGACGAGGTCTGGGGGATTGAGGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U4BSZ2


Antitoxin

Source ID Structure
AlphaFold DB G0TFR4

References