Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 839972..840681 Replicon chromosome
Accession NZ_CP095020
Organism Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)


Gene name vapC Uniprot ID P9WF74
Locus tag MUW65_RS03960 Protein ID WP_003403837.1
Coordinates 840253..840681 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag MUW65_RS03955 Protein ID WP_003403834.1
Coordinates 839972..840229 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW65_RS03950 (MUW65_03950) 837608..839881 + 2274 WP_016330384.1 PE family protein -
MUW65_RS03955 (MUW65_03955) 839972..840229 + 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
MUW65_RS03960 (MUW65_03960) 840253..840681 + 429 WP_003403837.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW65_RS03965 (MUW65_03965) 840762..840899 - 138 WP_003403839.1 hypothetical protein -
MUW65_RS03975 (MUW65_03975) 841058..841303 + 246 WP_003403841.1 hypothetical protein -
MUW65_RS03980 (MUW65_03980) 841372..842256 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
MUW65_RS03985 (MUW65_03985) 842267..843439 - 1173 WP_003403845.1 acyl-CoA dehydrogenase family protein -
MUW65_RS03990 (MUW65_03990) 843446..844978 - 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15831.27 Da        Isoelectric Point: 7.5536

>T240967 WP_003403837.1 NZ_CP095020:840253-840681 [Mycobacterium tuberculosis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

>T240967 NZ_LT897798:c528402-528085 [Vibrio cholerae]
ATGCAAAACAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAGAAACTACACCATTGAAAATTT
CGCTCAAGCACAATGGCTAAAATATAAATCGACCTTGCTTTCAGGTTTCCAGACTCTAGCGGATAATCCAGAGCTAGGAA
AAAGCTGTGAAGATATTTACAAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAGAC
TTCATTCTCATCGTCGCTGTATTAGGGCAATCACAGCTGCCCCAGAAACATCTCACACAATCACGTTTCGTTTCTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT240967 WP_003403834.1 NZ_CP095020:839972-840229 [Mycobacterium tuberculosis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT240967 NZ_LT897798:c528663-528421 [Vibrio cholerae]
ATGTACACACTAACAGCAAATGATGCTAAACGAAATTTTGGAGAACTTCTTCTAAGCGCACAGCGCGAGCCTGTCATAAT
CAGCAAAAACAGTAAAAATACTGTCGTTGTCATGTCCATTAAGGATTTTGAAGAACTTGAAGCCATGAAACTCGATTATC
TTAAACACTGCTTTGAGTCCGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCTACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDR3

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References