Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 716536..717200 Replicon chromosome
Accession NZ_CP095020
Organism Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)


Gene name vapC Uniprot ID P96917
Locus tag MUW65_RS03285 Protein ID WP_003403246.1
Coordinates 716793..717200 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WF18
Locus tag MUW65_RS03280 Protein ID WP_003403244.1
Coordinates 716536..716796 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW65_RS03255 (MUW65_03255) 712713..713777 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
MUW65_RS03260 (MUW65_03260) 713881..714828 + 948 WP_003403232.1 DUF732 domain-containing protein -
MUW65_RS03265 (MUW65_03265) 714921..715175 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 -
MUW65_RS03270 (MUW65_03270) 715175..715570 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 -
MUW65_RS03275 (MUW65_03275) 715664..716404 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
MUW65_RS03280 (MUW65_03280) 716536..716796 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUW65_RS03285 (MUW65_03285) 716793..717200 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW65_RS03290 (MUW65_03290) 717272..718423 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
MUW65_RS03295 (MUW65_03295) 718516..720243 - 1728 WP_003901883.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-57)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14376.37 Da        Isoelectric Point: 4.3568

>T240962 WP_003403246.1 NZ_CP095020:716793-717200 [Mycobacterium tuberculosis]
VSTTPAAGVLDTSVFIATESGRQLDEALIPDRVATTVVTLAELRVGVLAAATTDIRAQRLATLESVADMETLPVDDDAAR
MWARLRIHLAESGRRVRINDLWIAAVAASRALPVITQDDDFAALDGAASVEIIRV

Download         Length: 408 bp

>T240962 NZ_LT897798:503455-503721 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
GGTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9492.84 Da        Isoelectric Point: 11.9108

>AT240962 WP_003403244.1 NZ_CP095020:716536-716796 [Mycobacterium tuberculosis]
MSEVASRELRNDTAGVLRRVRAGEDVTITVSGRPVAVLTPVRPRRRRWLSKTEFLSRLRGAQADPGLRNDLAVLAGDTTE
DLGPIR

Download         Length: 261 bp

>AT240962 NZ_LT897798:503708-503953 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCTAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
ATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3DBO

Antitoxin

Source ID Structure
PDB 3DBO
AlphaFold DB A0A7U4BSE4

References