Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 714921..715570 Replicon chromosome
Accession NZ_CP095020
Organism Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag MUW65_RS03270 Protein ID WP_003403236.1
Coordinates 715175..715570 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag MUW65_RS03265 Protein ID WP_003403235.1
Coordinates 714921..715175 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW65_RS03240 (MUW65_03240) 710047..710130 + 84 Protein_642 galactose-1-phosphate uridylyltransferase -
MUW65_RS03245 (MUW65_03245) 710149..711230 + 1082 Protein_643 galactose-1-phosphate uridylyltransferase -
MUW65_RS03250 (MUW65_03250) 711227..712318 + 1092 WP_003900977.1 galactokinase -
MUW65_RS03255 (MUW65_03255) 712713..713777 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
MUW65_RS03260 (MUW65_03260) 713881..714828 + 948 WP_003403232.1 DUF732 domain-containing protein -
MUW65_RS03265 (MUW65_03265) 714921..715175 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
MUW65_RS03270 (MUW65_03270) 715175..715570 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
MUW65_RS03275 (MUW65_03275) 715664..716404 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
MUW65_RS03280 (MUW65_03280) 716536..716796 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MUW65_RS03285 (MUW65_03285) 716793..717200 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
MUW65_RS03290 (MUW65_03290) 717272..718423 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
MUW65_RS03295 (MUW65_03295) 718516..720243 - 1728 WP_003901883.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T240961 WP_003403236.1 NZ_CP095020:715175-715570 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T240961 NZ_LT897798:c497606-497289 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTAGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAGAC
TGCATTCTCATTGTCGCGGTATTAGGGCAATCACAGCTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT240961 WP_003403235.1 NZ_CP095020:714921-715175 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT240961 NZ_LT897798:c497867-497625 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAGCGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCTATTAAGGACTTTGAAGAACTTGAAGCCATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References