Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 709293..709918 Replicon chromosome
Accession NZ_CP095020
Organism Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag MUW65_RS03235 Protein ID WP_003403218.1
Coordinates 709517..709918 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag MUW65_RS03230 Protein ID WP_003403213.1
Coordinates 709293..709520 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW65_RS03205 (MUW65_03205) 704472..704693 - 222 WP_003898525.1 DUF4926 domain-containing protein -
MUW65_RS03210 (MUW65_03210) 704835..705440 + 606 WP_003898526.1 hypothetical protein -
MUW65_RS03215 (MUW65_03215) 705459..708026 - 2568 WP_003901879.1 SEC-C metal-binding domain-containing protein -
MUW65_RS03220 (MUW65_03220) 708110..708859 + 750 WP_003898528.1 hypothetical protein -
MUW65_RS03225 (MUW65_03225) 708856..709098 + 243 WP_003403210.1 hypothetical protein -
MUW65_RS03230 (MUW65_03230) 709293..709520 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
MUW65_RS03235 (MUW65_03235) 709517..709918 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
MUW65_RS03240 (MUW65_03240) 710047..710130 + 84 Protein_642 galactose-1-phosphate uridylyltransferase -
MUW65_RS03245 (MUW65_03245) 710149..711230 + 1082 Protein_643 galactose-1-phosphate uridylyltransferase -
MUW65_RS03250 (MUW65_03250) 711227..712318 + 1092 WP_003900977.1 galactokinase -
MUW65_RS03255 (MUW65_03255) 712713..713777 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
MUW65_RS03260 (MUW65_03260) 713881..714828 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T240960 WP_003403218.1 NZ_CP095020:709517-709918 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T240960 NZ_LT897798:496369-496638 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT240960 WP_003403213.1 NZ_CP095020:709293-709520 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT240960 NZ_LT897798:496632-497153 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References