Detailed information of TA system TA240951

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 361676..362202
• Replicon: chromosome
• Accession: NZ_CP095020
• Organism: Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: MUW65_RS01575
• Protein ID: WP_003401560.1
• Coordinates: 361900..362202 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: P9WJ08
• Locus tag: MUW65_RS01570
• Protein ID: WP_003401555.1
• Coordinates: 361676..361903 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUW65_RS01555 (MUW65_01555)	357369..358172	-	804	WP_003401540.1	Stf0 family sulphotransferase	-
MUW65_RS01560 (MUW65_01560)	358182..359579	-	1398	WP_003401544.1	sulfatase	-
MUW65_RS01565 (MUW65_01565)	359758..361533	+	1776	WP_010886074.1	PE family protein	-
MUW65_RS01570 (MUW65_01570)	361676..361903	+	228	WP_003401555.1	ribbon-helix-helix protein, CopG family	Antitoxin
MUW65_RS01575 (MUW65_01575)	361900..362202	+	303	WP_003401560.1	toxin-antitoxin system toxin	Toxin
MUW65_RS01580 (MUW65_01580)	362250..362471	+	222	WP_003401563.1	type II toxin-antitoxin system antitoxin VapB2	-
MUW65_RS01585 (MUW65_01585)	362468..362893	+	426	WP_003401566.1	PIN domain nuclease	-
MUW65_RS01590 (MUW65_01590)	363029..363661	+	633	WP_003905275.1	TetR/AcrR family transcriptional regulator	-
MUW65_RS01595 (MUW65_01595)	363658..364566	+	909	WP_003900117.1	protochlorophyllide reductase	-
MUW65_RS01600 (MUW65_01600)	364574..365164	-	591	WP_229298012.1	hypothetical protein	-
MUW65_RS01605 (MUW65_01605)	365157..365207	-	51	Protein_317	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10442.16 Da
• Isoelectric Point: 4.9609

>T240951 WP_003401560.1 NZ_CP095020:361900-362202 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Nucleotide

• Length: 303 bp

>T240951 NZ_LT883143:c5873958-5873680 [Pseudomonas aeruginosa C-NN2]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8130.21 Da
• Isoelectric Point: 7.0084

>AT240951 WP_003401555.1 NZ_CP095020:361676-361903 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Nucleotide

• Length: 228 bp

>AT240951 NZ_LT883143:c5873668-5873363 [Pseudomonas aeruginosa C-NN2]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Structures

Antitoxin

• AlphaFold DB: A0A7U4F8T1