Detailed information of TA system TA024095

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipB(antitoxin)
• Location: 483449..483943
• Replicon: chromosome
• Accession: NC_012962
• Organism: Photorhabdus asymbiotica

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: PAU_RS02155
• Protein ID: WP_012776627.1
• Coordinates: 483752..483943 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: PAU_RS02150
• Protein ID: WP_041381499.1
• Coordinates: 483449..483748 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PAU_RS02135	478891..481491	+	2601	WP_012776623.1	BREX-1 system phosphatase PglZ type A	-
PAU_RS02140	481794..482447	-	654	WP_012776624.1	TetR family transcriptional regulator	-
PAU_RS02145	482544..483209	+	666	WP_012776625.1	class I SAM-dependent methyltransferase	-
PAU_RS02150	483449..483748	+	300	WP_041381499.1	helix-turn-helix domain-containing protein	Antitoxin
PAU_RS02155	483752..483943	+	192	WP_012776627.1	HipA N-terminal domain-containing protein	Toxin
PAU_RS02160	484085..484894	-	810	WP_012776628.1	nucleotidyltransferase domain-containing protein	-
PAU_RS02165	484899..486071	-	1173	WP_197535158.1	RtcB family protein	-
PAU_RS02170	486784..486993	-	210	WP_012776630.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (3-52)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 6949.04 Da
• Isoelectric Point: 9.8576

>T24095 WP_012776627.1 NC_012962:483752-483943 [Photorhabdus asymbiotica]
MNKLVVALNGTIVGLLEKSAGGAMLFTYHESWLSRPGARAISLSLPLQKDSSDNRDRCYRILN

Nucleotide

• Length: 192 bp

>T24095 NC_012962:483752-483943 [Photorhabdus asymbiotica]
ATGAATAAACTCGTCGTTGCTCTTAATGGAACTATTGTCGGATTGTTAGAGAAATCTGCTGGTGGTGCGATGTTGTTTAC
TTACCATGAAAGCTGGTTATCCCGTCCGGGTGCACGTGCCATTTCTTTATCTCTCCCTTTACAGAAAGATTCGAGTGACA
ATAGAGATAGGTGTTATCGAATATTGAATTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11106.41 Da
• Isoelectric Point: 8.6217

>AT24095 WP_041381499.1 NC_012962:483449-483748 [Photorhabdus asymbiotica]
MSITSAKMLAHALRNERKKRKLSQGKVADSIGIKQSTVSEFENYPDGTRLETLFKLLAALDLELQVTKRGASLNSWSSSS
NTAQNQEGLHDQQGWDQEW

Nucleotide

• Length: 300 bp

>AT24095 NC_012962:483449-483748 [Photorhabdus asymbiotica]
ATGAGTATCACATCTGCAAAAATGTTGGCGCATGCTCTGCGTAATGAGCGTAAAAAGCGCAAATTAAGCCAGGGTAAAGT
TGCTGATAGCATTGGCATCAAACAGTCAACGGTTTCAGAGTTTGAGAATTACCCTGATGGAACCAGGCTTGAAACGTTGT
TTAAATTGCTCGCAGCTCTGGATTTGGAACTCCAGGTAACTAAACGAGGAGCGTCATTGAATTCCTGGTCATCATCCTCT
AATACAGCTCAAAACCAAGAAGGTTTGCATGATCAGCAGGGTTGGGATCAGGAGTGGTAG