Detailed information of TA system TA240949

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 4483752..4484284
• Replicon: chromosome
• Accession: NZ_CP095011
• Organism: Streptomyces sp. 2P-4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MUK52_RS19775
• Protein ID: WP_284578750.1
• Coordinates: 4483752..4484015 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MUK52_RS19780
• Protein ID: WP_284578752.1
• Coordinates: 4484012..4484284 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUK52_RS19745	4479260..4479451	-	192	WP_114057747.1	hypothetical protein	-
MUK52_RS19750	4479676..4480365	+	690	WP_114057746.1	cell division ATP-binding protein FtsE	-
MUK52_RS19755	4480385..4481317	+	933	WP_284578744.1	permease-like cell division protein FtsX	-
MUK52_RS19760	4481385..4482596	+	1212	WP_284578746.1	S41 family peptidase	-
MUK52_RS19765	4482616..4483101	+	486	WP_114057743.1	SsrA-binding protein SmpB	-
MUK52_RS19775	4483752..4484015	-	264	WP_284578750.1	Txe/YoeB family addiction module toxin	Toxin
MUK52_RS19780	4484012..4484284	-	273	WP_284578752.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
MUK52_RS19785	4484339..4485709	-	1371	WP_284578754.1	MFS transporter	-
MUK52_RS19790	4485794..4486768	+	975	WP_284578756.1	LysR family transcriptional regulator	-
MUK52_RS19795	4486865..4488235	+	1371	WP_114057738.1	nitrate/nitrite transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-71)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10338.79 Da
• Isoelectric Point: 10.0900

>T240949 WP_284578750.1 NZ_CP095011:c4484015-4483752 [Streptomyces sp. 2P-4]
VRSIHFDPAAWEDFLFWLGADRRMAKRITRLIGEIQRSPFTGIGKPEPLKGDLTGYWSRRIDDEHRLAYRADDKEVKILK
ARYRYSD

Nucleotide

• Length: 264 bp

>T240949 NZ_LT883143:c4658840-4658085 [Pseudomonas aeruginosa C-NN2]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGCTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGTGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9945.15 Da
• Isoelectric Point: 4.6412

>AT240949 WP_284578752.1 NZ_CP095011:c4484284-4484012 [Streptomyces sp. 2P-4]
VPISASEARKTLFPLIERVNNDHTPVRISSKNGDAVLMSADDYDAWQETVYLLRSPANARRLMEAVERDRAGTATVAKSM
EELQALAGEE

Nucleotide

• Length: 273 bp

>AT240949 NZ_LT883143:c4659343-4658975 [Pseudomonas aeruginosa C-NN2]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA