Detailed information of TA system TA240948

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 3834902..3835536
• Replicon: chromosome
• Accession: NZ_CP095011
• Organism: Streptomyces sp. 2P-4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MUK52_RS16905
• Protein ID: WP_284577582.1
• Coordinates: 3834902..3835324 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MUK52_RS16910
• Protein ID: WP_114058220.1
• Coordinates: 3835321..3835536 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUK52_RS16875	3829937..3830356	+	420	WP_114058224.1	TOBE domain-containing protein	-
MUK52_RS16880	3830463..3831128	+	666	WP_284577574.1	helix-turn-helix domain-containing protein	-
MUK52_RS16885	3831213..3831317	-	105	Protein_3338	restriction endonuclease	-
MUK52_RS16890	3831380..3831604	-	225	WP_162793317.1	hypothetical protein	-
MUK52_RS16895	3831654..3831977	-	324	WP_284577578.1	hypothetical protein	-
MUK52_RS16900	3831999..3834449	-	2451	WP_284577580.1	helicase-associated domain-containing protein	-
MUK52_RS16905	3834902..3835324	-	423	WP_284577582.1	PIN domain nuclease	Toxin
MUK52_RS16910	3835321..3835536	-	216	WP_114058220.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
MUK52_RS16915	3836126..3836401	+	276	WP_114058219.1	hypothetical protein	-
MUK52_RS16920	3836562..3836825	+	264	WP_284577586.1	PIN domain-containing protein	-
MUK52_RS16925	3836800..3837759	-	960	WP_114058218.1	HNH endonuclease	-
MUK52_RS16940	3838282..3840405	+	2124	WP_284577589.1	DNA polymerase III subunit gamma and tau	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-124)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-49)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15361.29 Da
• Isoelectric Point: 4.7118

>T240948 WP_284577582.1 NZ_CP095011:c3835324-3834902 [Streptomyces sp. 2P-4]
VNAALYLIDTSALARFMRGDAEQYGWDQAAAAGLIATCPVTELEFFYSARSAADRARGIEDMRLLFGWVPVDDRAYDRAW
QVQEALTKQGKHRSAGAVDLVVAATAELQGLTLLHCDHDFDCIAAVTGQPVQWYGPEGRK

Nucleotide

• Length: 423 bp

>T240948 NZ_LT883143:3734371-3734949 [Pseudomonas aeruginosa C-NN2]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTACTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8067.13 Da
• Isoelectric Point: 8.6590

>AT240948 WP_114058220.1 NZ_CP095011:c3835536-3835321 [Streptomyces sp. 2P-4]
MSRTVIDLDDELVADVAKALGTSTKKETVNTALREVLENRRRALALTRLRAAADEGSFDLTLFEDKRNYRR

Nucleotide

• Length: 216 bp

>AT240948 NZ_LT883143:3733728-3734282 [Pseudomonas aeruginosa C-NN2]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAATCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA