Detailed information of TA system TA240947

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 3065285..3065817
• Replicon: chromosome
• Accession: NZ_CP095011
• Organism: Streptomyces sp. 2P-4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MUK52_RS13170
• Protein ID: WP_284576300.1
• Coordinates: 3065285..3065539 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: MUK52_RS13175
• Protein ID: WP_114053619.1
• Coordinates: 3065536..3065817 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUK52_RS13150	3060783..3062576	+	1794	WP_284576297.1	arginine--tRNA ligase	-
MUK52_RS13155	3062734..3063342	+	609	WP_284576298.1	NAD(P)H-dependent oxidoreductase	-
MUK52_RS13160	3063449..3064276	+	828	WP_284576299.1	hypothetical protein	-
MUK52_RS13165	3064383..3065189	+	807	WP_114058399.1	VOC family protein	-
MUK52_RS13170	3065285..3065539	-	255	WP_284576300.1	Txe/YoeB family addiction module toxin	Toxin
MUK52_RS13175	3065536..3065817	-	282	WP_114053619.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
MUK52_RS13180	3065939..3066295	-	357	Protein_2610	ATP-binding protein	-
MUK52_RS13185	3066435..3067259	+	825	WP_284576301.1	helix-turn-helix transcriptional regulator	-
MUK52_RS13190	3067256..3067498	+	243	WP_284576302.1	DUF397 domain-containing protein	-
MUK52_RS13195	3067558..3067830	-	273	WP_114053617.1	DUF1876 domain-containing protein	-
MUK52_RS13200	3068358..3069032	-	675	WP_284576304.1	hypothetical protein	-
MUK52_RS13205	3069708..3070709	-	1002	WP_284576305.1	porphobilinogen synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-72)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10074.50 Da
• Isoelectric Point: 10.2335

>T240947 WP_284576300.1 NZ_CP095011:c3065539-3065285 [Streptomyces sp. 2P-4]
VKVVFSGRAWEQYTYWATADPKILKRINRLIGEIRRTPFEGTGKPEPLKENLSGWWSRRITDEHRLVYRIQDQAVEVAQV
RYHY

Nucleotide

• Length: 255 bp

>T240947 NZ_LT883143:2467589-2468164 [Pseudomonas aeruginosa C-NN2]
ATGAGGCATTCCCCATTCACCGCCGTCTACGACGCGTGCGTTCTATATCCCGCGCCACTGCGGGATTTCCTGATGTGGCT
CGGCCTGTCTGGCCGCTTCCGGGCGCGGTGGAGCCAAGCCATTCATGAGGAGTGGAAACGCAATCTGTTGATCAACCGCC
CCGATCTCACCCGGGTTCAGGTCGACAGGACGTCGGATCTCATGGACAGGGCCATTCCGGACGGCTTGGTGGAGGGCTAC
GAAGCGCTCGTGGCAGGCCTGACATTACCCGATCCGAACGATCGGCACGTCCTGGCTGCGGCGATTCGCTGCGGTGCGAG
CGTGATTGTGACGTTCAACGAACGTGATTTCCCGAACGATCTGCTGGCTCCGTACGGCATCGAATCGCAGCACCCCGATG
AGTTTGTGGACAACCTGCTGGATCTGGATGCGGCCGCCGTAGTGTCGGCTGCGCAGCGCCAGCGTGCCCAACTCAAGCAT
CCGCCGATCGATGTGGACCGCTATCTCGAAATCCTGCTGCGCCAAGGCCTTGTGCAAACGACCAAGGTGCTGGCGACCTA
TCGCACCATTCTCTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10492.60 Da
• Isoelectric Point: 4.1523

>AT240947 WP_114053619.1 NZ_CP095011:c3065817-3065536 [Streptomyces sp. 2P-4]
MSMSANEARQRFYPLIRQVNEDHVPIEVTSREHGDVVIMSAEDFRSWQETVYLLRSPRNAQILMESIAELDAGQGQAREL
ISVDDEEEAGSAA

Nucleotide

• Length: 282 bp

>AT240947 NZ_LT883143:2467122-2467592 [Pseudomonas aeruginosa C-NN2]
ATGACCACCGCCACTGCCCAATCCAAGATGACCCTTCCCGCCGCGGGAGAGGTTAAGGCAGCCGTCCAGGGTCAACGTGC
CTTGGCGGCTTACCTCGCAACCCAGTTCGAGACGCAGCACATCCAGATCTTTGATGACCACAAACAGGCTCATCAGGTGG
AACTGCCTACCTCGGCTTTACGCCTGCTGGTCGACATCCTGGCCGAGTTGGCCGATGGCAATGCAGTAAAGGTGGTGCCC
GTCCATGCAGAGCTGACGACCCAAGAGGCGGCGGACTTGCTCAACGTGTCCCGTCCCCATTTCGTCAAGCTGCTAGAAGA
TGGGGTGTTGGCATTTCATCGCACCGGCAAGCACCGCAGGGTGAGGTTCGCCGATCTGATGCAGTACAAGGAAGCGCGCG
AGCGCGCCAGTGAGCAGGCGATGGCCGAACTCGCTCAGCAGTCGCAAGAGTTGGGAATGGGATACGAATGA