Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 2620172..2620697 Replicon chromosome
Accession NZ_CP095011
Organism Streptomyces sp. 2P-4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MUK52_RS11000 Protein ID WP_284575796.1
Coordinates 2620434..2620697 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MUK52_RS10995 Protein ID WP_114053981.1
Coordinates 2620172..2620441 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUK52_RS10965 2615942..2616196 - 255 WP_284575788.1 Txe/YoeB family addiction module toxin -
MUK52_RS10970 2616193..2616468 - 276 WP_284575789.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
MUK52_RS10975 2616866..2617243 + 378 WP_284575791.1 CPCC family cysteine-rich protein -
MUK52_RS10980 2617240..2617980 + 741 WP_284575792.1 HEAT repeat domain-containing protein -
MUK52_RS10985 2617984..2618619 + 636 WP_284575793.1 DUF6000 family protein -
MUK52_RS10990 2618681..2619820 - 1140 WP_284575794.1 Fic family protein -
MUK52_RS10995 2620172..2620441 + 270 WP_114053981.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUK52_RS11000 2620434..2620697 + 264 WP_284575796.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MUK52_RS11005 2620832..2621920 - 1089 WP_114053980.1 redox-regulated ATPase YchF -
MUK52_RS11010 2622176..2622586 + 411 WP_284581692.1 hypothetical protein -
MUK52_RS11015 2622623..2623372 - 750 WP_284575798.1 ROK family protein -
MUK52_RS11020 2623394..2624401 - 1008 WP_114053977.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2616866..2634109 17243


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-56)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9996.37 Da        Isoelectric Point: 8.5042

>T240946 WP_284575796.1 NZ_CP095011:2620434-2620697 [Streptomyces sp. 2P-4]
VSEYRTAFRPEAQAELRKIPRDVALRILAKLTELETDPLGFNTTALASQPERRRLRVGDYRVVYTIDNGELAIWVVHVGH
RSTVYET

Download         Length: 264 bp

>T240946 NZ_LT883143:1931482-1932069 [Pseudomonas aeruginosa C-NN2]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10287.73 Da        Isoelectric Point: 4.6265

>AT240946 WP_114053981.1 NZ_CP095011:2620172-2620441 [Streptomyces sp. 2P-4]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIEVLRRYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARGE

Download         Length: 270 bp

>AT240946 NZ_LT883143:1932136-1932990 [Pseudomonas aeruginosa C-NN2]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTAGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTAGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAACAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATAGCGGCGTGCCGCGTTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGATGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGACAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCGTCCTTGACGACATACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References