240940

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 74147..74669 Replicon plasmid pA
Accession NZ_CP095000
Organism Klebsiella michiganensis strain fxq

Toxin (Protein)


Gene name stbE Uniprot ID A0A7H0EVH6
Locus tag MT472_RS29910 Protein ID WP_014839901.1
Coordinates 74147..74431 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A7H0EVH5
Locus tag MT472_RS29915 Protein ID WP_014839900.1
Coordinates 74421..74669 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT472_RS29875 (MT472_29875) 69742..70470 + 729 WP_042934505.1 thioredoxin fold domain-containing protein -
MT472_RS29880 (MT472_29880) 70487..70792 + 306 WP_014839905.1 hypothetical protein -
MT472_RS29885 (MT472_29885) 70806..71147 + 342 WP_042934503.1 hypothetical protein -
MT472_RS29890 (MT472_29890) 71211..71420 + 210 WP_125316032.1 hypothetical protein -
MT472_RS29895 (MT472_29895) 71483..72427 + 945 WP_014839903.1 DsbA family protein -
MT472_RS29900 (MT472_29900) 72523..73503 + 981 WP_000019402.1 IS5-like element IS5 family transposase -
MT472_RS29905 (MT472_29905) 73612..73956 - 345 WP_244673380.1 hypothetical protein -
MT472_RS29910 (MT472_29910) 74147..74431 - 285 WP_014839901.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MT472_RS29915 (MT472_29915) 74421..74669 - 249 WP_014839900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MT472_RS29920 (MT472_29920) 75010..76413 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
MT472_RS29925 (MT472_29925) 76442..77074 - 633 WP_001567369.1 hypothetical protein -
MT472_RS29930 (MT472_29930) 77293..78696 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
MT472_RS29935 (MT472_29935) 78725..79357 - 633 WP_001567369.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrS1 - 1..202694 202694
- inside IScluster/Tn - - 72523..78696 6173


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.46 Da        Isoelectric Point: 10.5831

>T240940 WP_014839901.1 NZ_CP095000:c74431-74147 [Klebsiella michiganensis]
MTYKLAFNESALKEWKKLGHTIREQFKKKLSERLQNPRVPAAQLHGGKDQYKIKLHGAGYRLVYSVNDEIVTVTVIGVGK
RNNDDIYNATRHRN

Download         Length: 285 bp

>T240940 NZ_LT883142:2676719-2676826 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCATCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9071.29 Da        Isoelectric Point: 3.8832

>AT240940 WP_014839900.1 NZ_CP095000:c74669-74421 [Klebsiella michiganensis]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMEMLEDQELGRIADERIGEDRIEVNID
DL

Download         Length: 249 bp

>AT240940 NZ_LT883142:c2676666-2676605 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0EVH6

Antitoxin

Source ID Structure
AlphaFold DB A0A7H0EVH5

References