24094

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 229834..230485 Replicon chromosome
Accession NC_012962
Organism Photorhabdus asymbiotica

Toxin (Protein)


Gene name hicA Uniprot ID W3V906
Locus tag PAU_RS01050 Protein ID WP_036778383.1
Coordinates 229834..230016 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A5C4RM69
Locus tag PAU_RS01055 Protein ID WP_012776405.1
Coordinates 230048..230485 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAU_RS01025 225496..225987 + 492 WP_012776401.1 CaiF/GrlA family transcriptional regulator -
PAU_RS01030 226023..226448 + 426 WP_041381465.1 hypothetical protein -
PAU_RS01035 226471..228588 - 2118 WP_012776403.1 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase -
PAU_RS01040 228606..228881 - 276 WP_011144672.1 DNA-directed RNA polymerase subunit omega -
PAU_RS01045 228936..229559 - 624 WP_012776404.1 guanylate kinase -
PAU_RS01050 229834..230016 + 183 WP_036778383.1 type II toxin-antitoxin system HicA family toxin Toxin
PAU_RS01055 230048..230485 + 438 WP_012776405.1 hypothetical protein Antitoxin
PAU_RS01060 230778..231638 - 861 WP_012776406.1 hypothetical protein -
PAU_RS01065 232545..233405 - 861 WP_012776407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-81)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6793.96 Da        Isoelectric Point: 11.0108

>T24094 WP_036778383.1 NC_012962:229834-230016 [Photorhabdus asymbiotica]
MKYSEFRRWLISQGVLIEKARGGGSHRKVSINGKSSVFPDHGSKEIPEPLRKKIMKDLGL

Download         Length: 183 bp

>T24094 NC_012962:229834-230016 [Photorhabdus asymbiotica]
ATGAAATACAGTGAGTTCCGCCGATGGCTAATTTCTCAAGGAGTTCTAATAGAGAAGGCTAGGGGTGGAGGAAGCCACCG
AAAGGTATCCATAAACGGTAAATCGTCGGTTTTCCCCGATCATGGTTCCAAAGAGATTCCTGAACCATTGAGGAAGAAAA
TAATGAAGGATCTGGGGCTTTAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16162.61 Da        Isoelectric Point: 4.8363

>AT24094 WP_012776405.1 NC_012962:230048-230485 [Photorhabdus asymbiotica]
MFNYPIKLEYDEETGSYVASCRDLPLFNSVGDSVDEALLESIDGLVTAISIEIDKRRPIPEASMLEAGEYIVTLPILVVM
KVALHNAMVETGTRKADLARRLGQKGPQIDRLLDVEHSSKVEVVELALHQLNRKLDIVVNTTLHH

Download         Length: 438 bp

>AT24094 NC_012962:230048-230485 [Photorhabdus asymbiotica]
ATGTTTAATTATCCTATAAAACTAGAATATGACGAAGAGACAGGAAGTTATGTGGCAAGTTGTCGTGATCTTCCCTTATT
CAACTCAGTCGGTGACTCAGTTGACGAAGCTCTTCTAGAATCTATTGATGGGTTGGTTACGGCTATTTCTATAGAAATTG
ACAAACGTCGGCCTATACCTGAAGCATCCATGTTGGAGGCAGGTGAATACATCGTCACTCTTCCTATTCTCGTCGTAATG
AAAGTGGCATTGCATAATGCAATGGTAGAAACAGGAACACGCAAAGCCGATCTTGCTCGACGGCTGGGACAAAAGGGGCC
GCAGATTGATCGGCTTCTTGATGTTGAACATTCATCAAAGGTTGAAGTTGTTGAATTGGCTTTGCATCAGTTAAATAGAA
AGCTAGATATAGTCGTTAATACTACATTACATCATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W3V906

Antitoxin

Source ID Structure
AlphaFold DB A0A5C4RM69

References