Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4838912..4839694 Replicon chromosome
Accession NZ_CP094999
Organism Klebsiella michiganensis strain fxq

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag MT472_RS23285 Protein ID WP_042944403.1
Coordinates 4838912..4839286 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag MT472_RS23290 Protein ID WP_042944401.1
Coordinates 4839338..4839694 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT472_RS23250 (MT472_23250) 4834136..4835239 + 1104 WP_004848066.1 glutamate 5-kinase -
MT472_RS23255 (MT472_23255) 4835250..4836503 + 1254 WP_014228088.1 glutamate-5-semialdehyde dehydrogenase -
MT472_RS23265 (MT472_23265) 4836793..4837639 - 847 Protein_4576 DUF4942 domain-containing protein -
MT472_RS23270 (MT472_23270) 4837721..4837924 - 204 WP_023568001.1 DUF957 domain-containing protein -
MT472_RS23275 (MT472_23275) 4837951..4838442 - 492 WP_042944408.1 DUF5983 family protein -
MT472_RS23280 (MT472_23280) 4838439..4838816 - 378 WP_042944406.1 TA system toxin CbtA family protein -
MT472_RS23285 (MT472_23285) 4838912..4839286 - 375 WP_042944403.1 TA system toxin CbtA family protein Toxin
MT472_RS23290 (MT472_23290) 4839338..4839694 - 357 WP_042944401.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MT472_RS23295 (MT472_23295) 4839746..4840390 - 645 WP_042944399.1 hypothetical protein -
MT472_RS23300 (MT472_23300) 4840406..4840627 - 222 WP_042944397.1 DUF987 domain-containing protein -
MT472_RS23305 (MT472_23305) 4840642..4841121 - 480 WP_042944395.1 DNA repair protein RadC -
MT472_RS23310 (MT472_23310) 4841133..4841603 - 471 WP_023567995.1 antirestriction protein -
MT472_RS23315 (MT472_23315) 4841684..4842505 - 822 WP_042944391.1 DUF932 domain-containing protein -
MT472_RS23320 (MT472_23320) 4842616..4842849 - 234 WP_042944390.1 DUF905 domain-containing protein -
MT472_RS23325 (MT472_23325) 4842937..4843884 - 948 WP_023567992.1 Ivy family c-type lysozyme inhibitor -
MT472_RS23330 (MT472_23330) 4843934..4844149 - 216 WP_042944388.1 hypothetical protein -
MT472_RS23335 (MT472_23335) 4844161..4844310 - 150 WP_001458941.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(18-110)

Antitoxin

Antitoxin CbeA

(15-113)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13571.26 Da        Isoelectric Point: 4.5407

>T240936 WP_042944403.1 NZ_CP094999:c4839286-4838912 [Klebsiella michiganensis]
MRIYPVSAKRAAEIERLSPVSPVAVWQRLLTYLLDRHYGLTLNDTQFGDDGTIQECIDVGDPLLDALNEVVEDDELERTD
NRGKSLLFRSSLLTPADIRNAQKAVGLAGNSASLIISGQSSARS

Download         Length: 375 bp

>T240936 NZ_LT883142:2250803-2251090 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13079.82 Da        Isoelectric Point: 6.3170

>AT240936 WP_042944401.1 NZ_CP094999:c4839694-4839338 [Klebsiella michiganensis]
MPDIPATNDNMDAPRWGLQRNITPCFGARLVQEGNRLHYLADRASINGTFSDADLRHLDQSFPLLLKQLELMLVSGELNP
RHQHSVTLYAKGLTCEADSLASHGYVYIAIYPTPATTA

Download         Length: 357 bp

>AT240936 NZ_LT883142:2250564-2250803 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References