Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 4644933..4645552 | Replicon | chromosome |
Accession | NZ_CP094999 | ||
Organism | Klebsiella michiganensis strain fxq |
Toxin (Protein)
Gene name | Hha | Uniprot ID | H3N9D8 |
Locus tag | MT472_RS22345 | Protein ID | WP_004099646.1 |
Coordinates | 4645334..4645552 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | H3N7X7 |
Locus tag | MT472_RS22340 | Protein ID | WP_004129911.1 |
Coordinates | 4644933..4645307 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MT472_RS22330 (MT472_22330) | 4640090..4641283 | + | 1194 | WP_042944463.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
MT472_RS22335 (MT472_22335) | 4641306..4644452 | + | 3147 | WP_014228207.1 | multidrug efflux RND transporter permease subunit AcrB | - |
MT472_RS22340 (MT472_22340) | 4644933..4645307 | + | 375 | WP_004129911.1 | Hha toxicity modulator TomB | Antitoxin |
MT472_RS22345 (MT472_22345) | 4645334..4645552 | + | 219 | WP_004099646.1 | HHA domain-containing protein | Toxin |
MT472_RS22350 (MT472_22350) | 4645715..4646281 | + | 567 | WP_042944461.1 | maltose O-acetyltransferase | - |
MT472_RS22355 (MT472_22355) | 4646253..4646387 | - | 135 | WP_223226764.1 | hypothetical protein | - |
MT472_RS22360 (MT472_22360) | 4646408..4646878 | + | 471 | WP_014228205.1 | YlaC family protein | - |
MT472_RS22365 (MT472_22365) | 4646853..4648307 | - | 1455 | WP_042944459.1 | PLP-dependent aminotransferase family protein | - |
MT472_RS22370 (MT472_22370) | 4648409..4649107 | + | 699 | WP_014228203.1 | GNAT family protein | - |
MT472_RS22375 (MT472_22375) | 4649104..4649244 | - | 141 | WP_003859006.1 | type B 50S ribosomal protein L36 | - |
MT472_RS22380 (MT472_22380) | 4649244..4649507 | - | 264 | WP_004848323.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8640.05 Da Isoelectric Point: 8.9008
>T240935 WP_004099646.1 NZ_CP094999:4645334-4645552 [Klebsiella michiganensis]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR
Download Length: 219 bp
>T240935 NZ_LT883142:1960930-1961033 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 125 a.a. Molecular weight: 14350.09 Da Isoelectric Point: 4.8989
>AT240935 WP_004129911.1 NZ_CP094999:4644933-4645307 [Klebsiella michiganensis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQIDEYL
DDTFVLFSNYGINSADLQKWRKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQIDEYL
DDTFVLFSNYGINSADLQKWRKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT240935 NZ_LT883142:c1961071-1960800 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3H713 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3HD25 |