Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pemIK/PRK09812-MazE |
Location | 2263571..2264161 | Replicon | chromosome |
Accession | NZ_CP094999 | ||
Organism | Klebsiella michiganensis strain fxq |
Toxin (Protein)
Gene name | pemK | Uniprot ID | A0A0H3HDW1 |
Locus tag | MT472_RS11145 | Protein ID | WP_014229979.1 |
Coordinates | 2263829..2264161 (+) | Length | 111 a.a. |
Antitoxin (Protein)
Gene name | pemI | Uniprot ID | J6I3K7 |
Locus tag | MT472_RS11140 | Protein ID | WP_004852307.1 |
Coordinates | 2263571..2263828 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MT472_RS11115 (MT472_11115) | 2258827..2259432 | - | 606 | WP_042945602.1 | glutathione S-transferase family protein | - |
MT472_RS11120 (MT472_11120) | 2259612..2260538 | + | 927 | WP_042945600.1 | LysR substrate-binding domain-containing protein | - |
MT472_RS11125 (MT472_11125) | 2260576..2261574 | - | 999 | WP_014229982.1 | aldo/keto reductase | - |
MT472_RS11130 (MT472_11130) | 2261675..2262589 | + | 915 | WP_042945598.1 | LysR family transcriptional regulator | - |
MT472_RS11135 (MT472_11135) | 2262780..2262860 | - | 81 | Protein_2185 | molybdopterin-binding protein | - |
MT472_RS11140 (MT472_11140) | 2263571..2263828 | + | 258 | WP_004852307.1 | antitoxin | Antitoxin |
MT472_RS11145 (MT472_11145) | 2263829..2264161 | + | 333 | WP_014229979.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
MT472_RS11155 (MT472_11155) | 2264484..2265941 | + | 1458 | WP_014229916.1 | EmmdR/YeeO family multidrug/toxin efflux MATE transporter | - |
MT472_RS11165 (MT472_11165) | 2266904..2268358 | - | 1455 | WP_014229909.1 | AMP nucleosidase | - |
MT472_RS11170 (MT472_11170) | 2268491..2268748 | - | 258 | WP_014229908.1 | histidine kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 11740.57 Da Isoelectric Point: 10.1863
>T240926 WP_014229979.1 NZ_CP094999:2263829-2264161 [Klebsiella michiganensis]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPITSGGNFARTAGFTVSLEGAGTKTTGVIRCDQPRTI
DMAARNGKRLESIPDAVVNEVLARLDAILS
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPITSGGNFARTAGFTVSLEGAGTKTTGVIRCDQPRTI
DMAARNGKRLESIPDAVVNEVLARLDAILS
Download Length: 333 bp
>T240926 NZ_LT883142:55206-55313 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9422.88 Da Isoelectric Point: 4.4607
>AT240926 WP_004852307.1 NZ_CP094999:2263571-2263828 [Klebsiella michiganensis]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL
Download Length: 258 bp
>AT240926 NZ_LT883142:c55157-55094 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3HDW1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3HDW8 |