240925

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1428132..1428685 Replicon chromosome
Accession NZ_CP094999
Organism Klebsiella michiganensis strain fxq

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag MT472_RS07055 Protein ID WP_016157234.1
Coordinates 1428371..1428685 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag MT472_RS07050 Protein ID WP_016157235.1
Coordinates 1428132..1428368 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT472_RS07035 (MT472_07035) 1424689..1425195 - 507 WP_032931759.1 hypothetical protein -
MT472_RS07040 (MT472_07040) 1425192..1426400 - 1209 WP_042945865.1 hypothetical protein -
MT472_RS07045 (MT472_07045) 1426865..1427809 + 945 WP_042945864.1 zincin-like metallopeptidase domain-containing protein -
MT472_RS07050 (MT472_07050) 1428132..1428368 + 237 WP_016157235.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
MT472_RS07055 (MT472_07055) 1428371..1428685 + 315 WP_016157234.1 CcdB family protein Toxin
MT472_RS07060 (MT472_07060) 1428682..1429434 - 753 WP_016157233.1 MobC family replication-relaxation protein -
MT472_RS07065 (MT472_07065) 1429443..1431179 - 1737 WP_042945862.1 type IV secretory system conjugative DNA transfer family protein -
MT472_RS07070 (MT472_07070) 1431956..1432261 - 306 WP_016157231.1 hypothetical protein -
MT472_RS07075 (MT472_07075) 1432308..1432610 - 303 WP_016157230.1 TrbM/KikA/MpfK family conjugal transfer protein -
MT472_RS07080 (MT472_07080) 1432659..1433057 - 399 WP_016157229.1 cag pathogenicity island Cag12 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1422383..1472932 50549


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11415.29 Da        Isoelectric Point: 8.9025

>T240925 WP_016157234.1 NZ_CP094999:1428371-1428685 [Klebsiella michiganensis]
MQFTVYGNTGKSAVYPLLLDVTSDIIGQLNRRIVIPLLPAGRYPAGRRPERLVPVVRLTDGQEYAVMTHELASVPVRALG
AVFCDASQYRTQVKAAIDFLIDGI

Download         Length: 315 bp

>T240925 NZ_LT883141:c67128-66817 [Escherichia coli]
ATGCACGTTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAACGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGACAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9044.08 Da        Isoelectric Point: 6.2206

>AT240925 WP_016157235.1 NZ_CP094999:1428132-1428368 [Klebsiella michiganensis]
MTAKQRSTQSVTMTVERALLIRAREAGINLSATLTTALDAELRHYEAKKWQEENREAIDALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp

>AT240925 NZ_LT883141:c66820-66401 [Escherichia coli]
ATGATGTACACCGATGCTATCCAGGCGGCAAACAGCCTGGTTAGCATTGTCCCCCTCCTGGGGGGCAATGCCTCTCGCAA
GGACTATGAAGACGCGCTGACGCTGGTTGAATACCTGGTTGAACACGAGCCAGATCATCCGCTGGTGGACATGCTGGTTG
CGAAAATTGCCCAGTATGAAGATGAGGCGGAAGAGTTCGCAGAGTTCAACGACCGTATTGCAGCGTTACCAAGTGGCGTG
GCCCTGCTGCGTGTCCTGATGGACCAGCACAAACTGACTCAGAGTGATTTTGAGGAAGAGATTGGTAAGAAATCGCTGGT
GAGCCGCATCCTTAACGGGACTCGCTCACTAACACTAGATCACATGAAAGCACTTGCGCGGCGCTTCAACATTCCGCCCA
GCTCATTCATGGACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References