Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 791720..792506 Replicon chromosome
Accession NZ_CP094999
Organism Klebsiella michiganensis strain fxq

Toxin (Protein)


Gene name yeeV Uniprot ID R8WN26
Locus tag MT472_RS03855 Protein ID WP_016154457.1
Coordinates 791720..792097 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A242VSK1
Locus tag MT472_RS03860 Protein ID WP_009652436.1
Coordinates 792147..792506 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT472_RS03830 (MT472_03830) 787983..789371 + 1389 WP_042946044.1 DASS family sodium-coupled anion symporter -
MT472_RS03835 (MT472_03835) 789498..790061 - 564 WP_244673308.1 hypothetical protein -
MT472_RS03840 (MT472_03840) 790073..790918 - 846 Protein_752 DUF4942 domain-containing protein -
MT472_RS03845 (MT472_03845) 790999..791202 - 204 WP_009652505.1 DUF957 domain-containing protein -
MT472_RS03850 (MT472_03850) 791232..791723 - 492 WP_009652438.1 DUF5983 family protein -
MT472_RS03855 (MT472_03855) 791720..792097 - 378 WP_016154457.1 TA system toxin CbtA family protein Toxin
MT472_RS03860 (MT472_03860) 792147..792506 - 360 WP_009652436.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MT472_RS03865 (MT472_03865) 792530..792751 - 222 WP_009652392.1 DUF987 domain-containing protein -
MT472_RS03870 (MT472_03870) 792765..793247 - 483 WP_016154455.1 DNA repair protein RadC -
MT472_RS03875 (MT472_03875) 793259..793477 - 219 WP_009652503.1 hypothetical protein -
MT472_RS03880 (MT472_03880) 793488..793961 - 474 WP_009652453.1 antirestriction protein -
MT472_RS03885 (MT472_03885) 793978..794232 - 255 WP_009652519.1 hypothetical protein -
MT472_RS03890 (MT472_03890) 794232..795050 - 819 WP_009652424.1 DUF932 domain-containing protein -
MT472_RS03895 (MT472_03895) 795154..795387 - 234 WP_009652474.1 DUF905 domain-containing protein -
MT472_RS03900 (MT472_03900) 795443..795664 - 222 WP_009652443.1 hypothetical protein -
MT472_RS03905 (MT472_03905) 795747..796259 - 513 WP_009652395.1 DUF4234 domain-containing protein -
MT472_RS03910 (MT472_03910) 796308..796778 - 471 WP_009652431.1 hypothetical protein -
MT472_RS03915 (MT472_03915) 796825..797136 - 312 WP_009652410.1 hypothetical protein -
MT472_RS03920 (MT472_03920) 797149..797415 - 267 WP_009652486.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14168.19 Da        Isoelectric Point: 9.5224

>T240923 WP_016154457.1 NZ_CP094999:c792097-791720 [Klebsiella michiganensis]
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP

Download         Length: 378 bp

>T240923 NZ_LT882487:c22646-22365 [Salmonella enterica subsp. enterica serovar Typhi]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13286.19 Da        Isoelectric Point: 6.4780

>AT240923 WP_009652436.1 NZ_CP094999:c792506-792147 [Klebsiella michiganensis]
MSNTIPPVNHDIAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELN
PRHQHCVTLYAKGLICEADSLGSHGYVYLAIYPTPATTE

Download         Length: 360 bp

>AT240923 NZ_LT882487:c22912-22643 [Salmonella enterica subsp. enterica serovar Typhi]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8WN26

Antitoxin

Source ID Structure
AlphaFold DB A0A242VSK1

References