Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 57321..57868 | Replicon | chromosome |
| Accession | NZ_CP094999 | ||
| Organism | Klebsiella michiganensis strain fxq | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | A0A0H3H5T3 |
| Locus tag | MT472_RS00290 | Protein ID | WP_014227299.1 |
| Coordinates | 57321..57629 (-) | Length | 103 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | A0A0H3H0P7 |
| Locus tag | MT472_RS00295 | Protein ID | WP_014227298.1 |
| Coordinates | 57632..57868 (-) | Length | 79 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MT472_RS00260 (MT472_00260) | 52968..53279 | - | 312 | WP_014227304.1 | PTS sugar transporter subunit IIB | - |
| MT472_RS00265 (MT472_00265) | 53574..54515 | + | 942 | WP_014227303.1 | LacI family DNA-binding transcriptional regulator | - |
| MT472_RS00270 (MT472_00270) | 54539..54832 | - | 294 | WP_014227302.1 | YicS family protein | - |
| MT472_RS00275 (MT472_00275) | 55042..56007 | + | 966 | WP_038423881.1 | Rpn family recombination-promoting nuclease/putative transposase | - |
| MT472_RS00280 (MT472_00280) | 56007..56264 | + | 258 | WP_042946138.1 | hypothetical protein | - |
| MT472_RS00285 (MT472_00285) | 56268..57170 | - | 903 | WP_014227300.1 | EamA family transporter | - |
| MT472_RS00290 (MT472_00290) | 57321..57629 | - | 309 | WP_014227299.1 | CcdB family protein | Toxin |
| MT472_RS00295 (MT472_00295) | 57632..57868 | - | 237 | WP_014227298.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
| MT472_RS00300 (MT472_00300) | 57974..59407 | - | 1434 | WP_032718833.1 | PTS N-acetylmuramic acid transporter subunit IIBC | - |
| MT472_RS00305 (MT472_00305) | 59432..60334 | - | 903 | WP_009654080.1 | N-acetylmuramic acid 6-phosphate etherase | - |
| MT472_RS00310 (MT472_00310) | 60495..61661 | - | 1167 | WP_042946137.1 | multidrug effflux MFS transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 103 a.a. Molecular weight: 11725.57 Da Isoelectric Point: 7.2729
>T240922 WP_014227299.1 NZ_CP094999:c57629-57321 [Klebsiella michiganensis]
MQYYVYKNTGRIAAYPYLLDVQSDIIGKRNTRVVIPLFPLKNYKGPRADRLTPLVTVEGEEYVVMTHELASIPHRVLGEE
VCNLNHQREVVKASMDFLFDGI
MQYYVYKNTGRIAAYPYLLDVQSDIIGKRNTRVVIPLFPLKNYKGPRADRLTPLVTVEGEEYVVMTHELASIPHRVLGEE
VCNLNHQREVVKASMDFLFDGI
Download Length: 309 bp
>T240922 NZ_LT859959:c7511534-7510956 [Bradyrhizobium sp. ORS 285]
ATTAGCAACCACTCTCGCTACACCGTCATCCTCGACGCTTGCACTCTATACCCAGCCCCACTGCGGGATCTTTTGATGGA
GACCGCGTCGATGGGACTGTTTCGCGCAAAATGGAGCGACAGAATCCACGATGAGTGGATCTCCAACCTGCTTGCAAAGC
GGCCAGATCTCGACCTGGCGAAACTCGAGAGAACAAGACACTTGATGAACAACGCCGTTCCCGATTGTCTGGTCACCGGG
TACGAATCTATCATTGACGCCCTCGATCTACCTGACGAAGACGACCGACACGTGTTGGCGGCCGGCATTCACTGCGGCGC
AGACGCCATCGTGACGTTTAACGTCAAAGACTTTCCCGTAGAGACGCTGGCAATCCACCATATCGAACCACAGCACCCCG
ACGAATTCCTCGTGCACCAGTTTGGACTGAACGAGGCAGCGGTCCTGAATGCCGCGCGCCGATGCAGGTTGAGGCTGAAG
AGAAATCCCAGGGACGCCATCCAGTATTTGCTCGCCCTCGAAAGATGCGGACTCCCCCAAACTGTCGCGCACCTTCGCGC
CTACTCTGAGGTCATTTAA
ATTAGCAACCACTCTCGCTACACCGTCATCCTCGACGCTTGCACTCTATACCCAGCCCCACTGCGGGATCTTTTGATGGA
GACCGCGTCGATGGGACTGTTTCGCGCAAAATGGAGCGACAGAATCCACGATGAGTGGATCTCCAACCTGCTTGCAAAGC
GGCCAGATCTCGACCTGGCGAAACTCGAGAGAACAAGACACTTGATGAACAACGCCGTTCCCGATTGTCTGGTCACCGGG
TACGAATCTATCATTGACGCCCTCGATCTACCTGACGAAGACGACCGACACGTGTTGGCGGCCGGCATTCACTGCGGCGC
AGACGCCATCGTGACGTTTAACGTCAAAGACTTTCCCGTAGAGACGCTGGCAATCCACCATATCGAACCACAGCACCCCG
ACGAATTCCTCGTGCACCAGTTTGGACTGAACGAGGCAGCGGTCCTGAATGCCGCGCGCCGATGCAGGTTGAGGCTGAAG
AGAAATCCCAGGGACGCCATCCAGTATTTGCTCGCCCTCGAAAGATGCGGACTCCCCCAAACTGTCGCGCACCTTCGCGC
CTACTCTGAGGTCATTTAA
Antitoxin
Download Length: 79 a.a. Molecular weight: 8783.92 Da Isoelectric Point: 5.7928
>AT240922 WP_014227298.1 NZ_CP094999:c57868-57632 [Klebsiella michiganensis]
MPAAKRNKQNVSVTLDPGLVKQAREVGINLSLTLTNALKSEIHSLEIARWQKENAQAIDYLNNLTEENGLLSDEYRTF
MPAAKRNKQNVSVTLDPGLVKQAREVGINLSLTLTNALKSEIHSLEIARWQKENAQAIDYLNNLTEENGLLSDEYRTF
Download Length: 237 bp
>AT240922 NZ_LT859959:c7511976-7511530 [Bradyrhizobium sp. ORS 285]
ATGAGCGCACGAGATCTAGAGAGACCAATCACGCTTCCTTCGAAGGAAGATACCGCCCTTGCCCAGGAAGCTTCGAGAGC
CATTGCAACGAAGCAGCCTTCAGAGCTCAAGGTCAGATTGGACGACGGCCAAGAACTCACCTTGCCGAAGGCGGCCACAC
GGCTCATCGCCCATCTTCTGACAGAGATGGCTCAGGGCAATGCGGTCACGATCATTCCCATCCATGCGGTGCTGACGACA
CAGGAGGCGGCAGACTATCTAAACGTCTCGAGGCCACATCTCGTCAGCTTGCTCGAGGAAAAAAGGATTCCCTACCACAA
GGTGGGAACACATCGACGCGTTCGATTCCAGGATCTCGTCGATTATCGCGCAGCGTTCGAGAAGCGCCGCCGGGAGATCA
TGGAGGAGCTTGCGGCTCAAGCCGAGCAAGAGGACATGGGCTATTAG
ATGAGCGCACGAGATCTAGAGAGACCAATCACGCTTCCTTCGAAGGAAGATACCGCCCTTGCCCAGGAAGCTTCGAGAGC
CATTGCAACGAAGCAGCCTTCAGAGCTCAAGGTCAGATTGGACGACGGCCAAGAACTCACCTTGCCGAAGGCGGCCACAC
GGCTCATCGCCCATCTTCTGACAGAGATGGCTCAGGGCAATGCGGTCACGATCATTCCCATCCATGCGGTGCTGACGACA
CAGGAGGCGGCAGACTATCTAAACGTCTCGAGGCCACATCTCGTCAGCTTGCTCGAGGAAAAAAGGATTCCCTACCACAA
GGTGGGAACACATCGACGCGTTCGATTCCAGGATCTCGTCGATTATCGCGCAGCGTTCGAGAAGCGCCGCCGGGAGATCA
TGGAGGAGCTTGCGGCTCAAGCCGAGCAAGAGGACATGGGCTATTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3H5T3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3H0P7 |