Detailed information of TA system TA240919

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 3259705..3260390
• Replicon: chromosome
• Accession: NZ_CP094998
• Organism: Synechocystis sp. PCC 6803 substr. GT-T

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A6P1VMJ8
• Locus tag: MT986_RS15220
• Protein ID: WP_010874101.1
• Coordinates: 3259705..3260100 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MT986_RS15225
• Protein ID: WP_010874102.1
• Coordinates: 3260112..3260390 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MT986_RS15205 (MT986_15205)	3255334..3257529	-	2196	WP_010874098.1	phosphoketolase	-
MT986_RS15210 (MT986_15210)	3257778..3258917	-	1140	WP_010874099.1	site-2 protease family protein	-
MT986_RS15215 (MT986_15215)	3259047..3259703	+	657	WP_010874100.1	YggS family pyridoxal phosphate-dependent enzyme	-
MT986_RS15220 (MT986_15220)	3259705..3260100	-	396	WP_010874101.1	type II toxin-antitoxin system VapC family toxin	Toxin
MT986_RS15225 (MT986_15225)	3260112..3260390	-	279	WP_010874102.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MT986_RS15230 (MT986_15230)	3260460..3261803	-	1344	WP_010874103.1	FIST C-terminal domain-containing protein	-
MT986_RS15235 (MT986_15235)	3261931..3264663	+	2733	WP_010874104.1	valine--tRNA ligase	-
MT986_RS15240 (MT986_15240)	3264885..3265190	-	306	WP_197525966.1	NADH-quinone oxidoreductase subunit NuoK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 15081.50 Da
• Isoelectric Point: 4.5594

>T240919 WP_010874101.1 NZ_CP094998:c3260100-3259705 [Synechocystis sp. PCC 6803]
VKLLLDTQCWLWWFTEPEKLNEDAISQIIDETNEIWLSVASIWEMSIKTSIGKLPLPENIDDYILSRMVKLGAEFLDIKT
RHALQVATLPLHHRDPFDRIIIAQAQTENMLLISADSMFKNYGVSLLWAGV

Nucleotide

• Length: 396 bp

>T240919 NZ_LT859959:c5981371-5981183 [Bradyrhizobium sp. ORS 285]
ATGAACAGTCGGGACGTGATCTCGGTTCTGCAACGGGACGGGTGGGTTCAAATCGCCCAGAAGGGCAGCCACGTCCAATT
CAAGCATCCGTCCAAAAAGGGACGAGTGACCGTTCCTCATCCGTCGCGAGACCTCCCGATCGGCACGCTGAAAAGCATCG
AGAAGCAAGCAGGTCTCAAGCTGAGGTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10084.59 Da
• Isoelectric Point: 4.0201

>AT240919 WP_010874102.1 NZ_CP094998:c3260390-3260112 [Synechocystis sp. PCC 6803]
MIGVSVNPEKLGSTMETVNVDQIEINLPELLYSIKPGEEVIVADQGIPIAKLVPLQRQKSVDRCSSLGVDRGLFVVPDDF
NDPLPNDIWPLS

Nucleotide

• Length: 279 bp

>AT240919 NZ_LT859959:c5981177-5980776 [Bradyrhizobium sp. ORS 285]
ATGCGGTACTACATCGGTCTCATTCACAAGGATGCTGATAGCCATTTCGGCGTCTCATTTCCGGATTTGCCCGGCGTCGT
GACAGCGGGGACAACTCTGGATGACGCGCGGGTGATGGCCGAGGAAGCCCTGGCGTTACATATCGAAGGTCTCGTCGAGG
ACGGCGAAGCCATTCCCGAGCCATCCTCACTGGAGCAGATCATGTCCCATCGAACCAACCGCTCCGGCGTCGCTGTTCTC
GTTCCAGCCAAGGTCGAGCAGTCCAGGGCAGTGCGCGTGAATGTCACGCTGCCCGAAGACGTGCTGGCCCAAATCGATCG
CTATGCCGAAGCGCACGGCTTTACCCGGTCCGGGTTGTTGGTGCAGGCGGCCAAAAAGCTCATGACGGACGAGGCGGCCT
GA

Structures

Toxin

• AlphaFold DB: A0A6P1VMJ8