Detailed information of TA system TA240918

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2513791..2514390
• Replicon: chromosome
• Accession: NZ_CP094998
• Organism: Synechocystis sp. PCC 6803 substr. GT-T

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MT986_RS11800
• Protein ID: WP_010873447.1
• Coordinates: 2513791..2514168 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MT986_RS11805
• Protein ID: WP_010873448.1
• Coordinates: 2514169..2514390 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MT986_RS11785 (MT986_11785)	2509155..2509850	-	696	WP_010873444.1	aldehyde oxygenase (deformylating)	-
MT986_RS11790 (MT986_11790)	2510108..2511205	-	1098	WP_014407137.1	glucose-1-phosphate thymidylyltransferase	-
MT986_RS11795 (MT986_11795)	2511447..2513615	+	2169	WP_010873446.1	glycine--tRNA ligase subunit beta	-
MT986_RS11800 (MT986_11800)	2513791..2514168	-	378	WP_010873447.1	type II toxin-antitoxin system VapC family toxin	Toxin
MT986_RS11805 (MT986_11805)	2514169..2514390	-	222	WP_010873448.1	DUF2281 domain-containing protein	Antitoxin
MT986_RS11810 (MT986_11810)	2514455..2515825	-	1371	WP_010873449.1	FADH(2)-oxidizing methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))- methyltransferase TrmFO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• VapC-like Sll0205 protein, PIN domain (2-124)

Antitoxin

• Domain of unknown function DUF2281 (6-72)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14761.18 Da
• Isoelectric Point: 7.0607

>T240918 WP_010873447.1 NZ_CP094998:c2514168-2513791 [Synechocystis sp. PCC 6803]
MLLDTHTLLWFLDNDIKLPSHLKSLIEAKPKVYVSIVSLWEIAIKLNINKLRLNYAFTDLENLLADLNISVLNITWQHLE
ACRNLPLHHRDPFDRMIIAQAQQHNFSVISKDENFKKYNVNLIWE

Nucleotide

• Length: 378 bp

>T240918 NZ_LT859959:4076675-4077073 [Bradyrhizobium sp. ORS 285]
GTGAGCACGTTCTTCGACAGCAACATTCTCGTCTACGCCTATTCCACTGACCCGCGGCGTGATCGCGCTATTGATGTGAT
CGCCGATGGTGGCGTCATCAGCGTCCAGGTGCTGAACGAGTTCACCAACGTTTTGCGCAGAAAGCAGAAGCTCGACTGGC
CTACCGTCGAAGCCGCGCTATCCTCAATCATCTTTCGTTTCCCCGACGCGCGGCCATTGACCGTGGCTACCCACACCACG
GCGATCGCCCTCGCCCGCGATCACGGCCTGCAATTCTACGATGCTCTCATCGTCGCCTCAGCGCTAGACGCCGACTGCGA
TACCCTCGTCAGTGAAGACTTGCAGCACGGTCGCAGCTTTGGCAGCCTCACGATCGTCAACCCGTTCCTGGGTTTATGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8355.66 Da
• Isoelectric Point: 4.3855

>AT240918 WP_010873448.1 NZ_CP094998:c2514390-2514169 [Synechocystis sp. PCC 6803]
MTDTALLEKINALPDAMKIEVEHFVEFLLTKQPPVSPVTNDGQKKYRQAGVLKGKIWMADDFDAPLEEMQEYM

Nucleotide

• Length: 222 bp

>AT240918 NZ_LT859959:4076448-4076678 [Bradyrhizobium sp. ORS 285]
ATGCAGGTTATCAAAGTGGACGACAGCCTTGCGGTGCTATTGCCCAAAAAGCTGGTCGACGAGCTCGGCATCAAGGAAGG
TGACGACGTCAGCGTCCTTTCGCTCGCCAAGGACGCGATCGCGGTGCAGAAGGCCGCAACGCGCGCCGAGTTCCTGAAGC
AAATCGAGCCATTGCGTTTTCCTCTCCCCGCAGACTACAAGTTTGACCGGGACGAGGCAAACGGGCGGTGA