Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1932286..1932878 Replicon chromosome
Accession NZ_CP094998
Organism Synechocystis sp. PCC 6803 substr. GT-T

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MT986_RS09195 Protein ID WP_010872957.1
Coordinates 1932286..1932672 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MT986_RS09200 Protein ID WP_010872958.1
Coordinates 1932672..1932878 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT986_RS09185 (MT986_09185) 1929957..1931129 + 1173 WP_010872955.1 sulfate adenylyltransferase -
MT986_RS09190 (MT986_09190) 1931172..1932236 + 1065 WP_010872956.1 glycosyltransferase -
MT986_RS09195 (MT986_09195) 1932286..1932672 - 387 WP_010872957.1 type II toxin-antitoxin system VapC family toxin Toxin
MT986_RS09200 (MT986_09200) 1932672..1932878 - 207 WP_010872958.1 DUF2281 domain-containing protein Antitoxin
MT986_RS09205 (MT986_09205) 1933125..1934348 - 1224 WP_010872959.1 geranylgeranyl reductase -
MT986_RS09210 (MT986_09210) 1934730..1935887 + 1158 WP_010872960.1 oxidoreductase -
MT986_RS09215 (MT986_09215) 1935904..1936215 + 312 WP_010872961.1 DUF433 domain-containing protein -
MT986_RS09220 (MT986_09220) 1936292..1937128 + 837 WP_010872962.1 LapA family protein -
MT986_RS09225 (MT986_09225) 1937247..1937600 + 354 WP_010872963.1 TMEM165/GDT1 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-127)

Antitoxin

Domain of unknown function DUF2281

(7-67)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14814.14 Da        Isoelectric Point: 6.0713

>T240917 WP_010872957.1 NZ_CP094998:c1932672-1932286 [Synechocystis sp. PCC 6803]
MNSVLIDTHVFIWLAEDDSNLPVTTKDTLENMDNVFVSIASFWEISIKLKIGKLSLCGDFNSIEASFQRTRFKLLPITLK
DTIKLYNLPLHHKDPFDRILVSQSINHSLILVSRDQALDDYPIQRLWL

Download         Length: 387 bp

>T240917 NZ_LT855380:c5512998-5512645 [Pseudomonas viridiflava]
ATGCGGGTAATAGCAAAAACGACGGTTGCGAAAGCCATCGAAGCTCATGGTCAGTGGAAGGCGGCACTGAGTTTGTGGCT
GACCACCTTTGACAGGGCGACTCTGCGCTTTGAGTCCTTCGAGCAGCTTCGAGATACCTGGGTCACCGCTTCTGGATGGA
ACATTGACCGAATTCCCTGCTCGAAGCTGAGACAGCCGAGCGTTAAAGGGCCTCTTGATGTGTATGTCTTCGACATCAAG
AAAAATGAGTGCCGGATTATTGCGTGGATTAATACCCGGAATGGCACTATTTATATAAAGGATATTCTGCCCCACGCCGG
TTATGACAAGTGGTGCAAGAGTGACGTTAAGTAG

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7699.84 Da        Isoelectric Point: 3.8804

>AT240917 WP_010872958.1 NZ_CP094998:c1932878-1932672 [Synechocystis sp. PCC 6803]
MTTEAALLNIAENLPDDLKIELLHYAEYLMNKSLNAPQKPLAGSMKGTFILPLPEDFDAPLEEFEEYM

Download         Length: 207 bp

>AT240917 NZ_LT855380:c5512592-5512119 [Pseudomonas viridiflava]
ATGAAGCATGATAAGAACGGAGCCACTGGGCTGGATTCCTTCATCGCTAACATTTCACCGATGCTTGATGGCTTAAGCGA
TCAGATAGCAACGATGGCCCAGTTATTGGCTGCCTGTCATGATCCCGTCAAGAGTGACACTGACTTGAAGGGGCGGATGG
CGCTGATCGATGAGCTTTACTCTCATGCAGACAGTGAAGATCACGCAGCCGCGCGCTTTGCGGAGCTGGTGGCCGAGCGT
GTGTATGAGTACGAGACTGAAACCGTTTTGATTCCTTACTCATCTCAGGCGGAAGCACTGGCTTTCCTGATTTCGGACAG
GGGAGTCAGACAGAAGGATTTGTCAGGTGTTGCCACTCAAAGTGCTGTTTCCGAGATACTGAACAACAAGAGGAAAATGA
CGGTTGCTCAGATAAAAGGCTTTGCAGAATTCTTTAAAGTGCCCGTCGAGTTTTTCATGCATGGCGTCGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References