Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /RES-TIGR02293 |
Location | 148899..149809 | Replicon | plasmid pB-8919_OXA-48 |
Accession | NZ_CP094992 | ||
Organism | Klebsiella pneumoniae strain SCPM-O-B-8919 (12PKP/19c) |
Toxin (Protein)
Gene name | - | Uniprot ID | A0A663AYG0 |
Locus tag | KF986_RS26900 | Protein ID | WP_004026354.1 |
Coordinates | 149339..149809 (+) | Length | 157 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | A0A6P1V3Q9 |
Locus tag | KF986_RS26895 | Protein ID | WP_004026357.1 |
Coordinates | 148899..149342 (+) | Length | 148 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KF986_RS26870 (KF986_026870) | 144055..144270 | - | 216 | Protein_174 | IS200/IS605 family transposase | - |
KF986_RS26875 (KF986_026875) | 144272..144841 | + | 570 | Protein_175 | transposase | - |
KF986_RS26880 (KF986_026880) | 145209..146696 | - | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
KF986_RS26885 (KF986_026885) | 147106..147528 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
KF986_RS26890 (KF986_026890) | 147528..148799 | + | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
KF986_RS26895 (KF986_026895) | 148899..149342 | + | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
KF986_RS26900 (KF986_026900) | 149339..149809 | + | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
KF986_RS26905 (KF986_026905) | 149918..150178 | - | 261 | WP_004026352.1 | hypothetical protein | - |
KF986_RS26915 (KF986_026915) | 151205..151864 | + | 660 | WP_000412211.1 | type A-1 chloramphenicol O-acetyltransferase | - |
KF986_RS26920 (KF986_026920) | 152065..152442 | - | 378 | WP_000656305.1 | GNAT family N-acetyltransferase | - |
KF986_RS26925 (KF986_026925) | 152509..153342 | - | 834 | Protein_185 | Tn3 family transposase | - |
KF986_RS26930 (KF986_026930) | 153407..154111 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
KF986_RS26935 (KF986_026935) | 154165..154605 | - | 441 | Protein_187 | CatB-related O-acetyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | blaOXA-48 / catA1 / blaOXA-1 / aac(6')-Ib-cr / blaTEM-1B / qnrS1 / blaCTX-M-15 / ant(2'')-Ia / ant(3'')-Ia / qacE / sul1 | iucA / iucB / iucC / iucD / iutA / rmpA2 | 1..326663 | 326663 | |
- | flank | IS/Tn | - | - | 144488..144841 | 353 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T240907 WP_004026354.1 NZ_CP094992:149339-149809 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T240907 NZ_LT853885:c4197495-4197214 [Xanthomonas fragariae]
ATGATCAAGAGCATTGTCGACAAGGAAGCCGAAAAGATCTGGGTGGGTGAGCGCTCCCGCCGGTTGCCGGCCGACATCCA
GTCGGTCGCGCGCCGCAAGTTGCGCATGCTCAACGCTGCCGCGCACCTCGACGATCTGCGCATTCCGCCTGCCAACCGGC
TGGAAGCGTTGAAGGGCGAGCGGCGCGGGCAGTACAGCATCCGGATCAACGACCAGTTGCGCATCTGCTTCCGATGGATG
GAGGGCGATGTCGCCGAGGTCGAAATTGTCGATTACCACTGA
ATGATCAAGAGCATTGTCGACAAGGAAGCCGAAAAGATCTGGGTGGGTGAGCGCTCCCGCCGGTTGCCGGCCGACATCCA
GTCGGTCGCGCGCCGCAAGTTGCGCATGCTCAACGCTGCCGCGCACCTCGACGATCTGCGCATTCCGCCTGCCAACCGGC
TGGAAGCGTTGAAGGGCGAGCGGCGCGGGCAGTACAGCATCCGGATCAACGACCAGTTGCGCATCTGCTTCCGATGGATG
GAGGGCGATGTCGCCGAGGTCGAAATTGTCGATTACCACTGA
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT240907 WP_004026357.1 NZ_CP094992:148899-149342 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT240907 NZ_LT853885:c4197195-4196905 [Xanthomonas fragariae]
ATGACAGTCCTACCCAACATCCACCCTGGTGAAATCCTGCTTGAGGAGTTCCTCGAGCCGATGGGCATCAGCCAGAACGC
ATTGGCGCGGGCCACCGGTGTGCCGCCGCGCCGTATCAACGAAATCGTGTTGGGCAAGCGCGGCATCACCGCCGACACCG
CCGTGCGCCTGGCTGCAGCGCTGTGCACGACCGAGCGCTTCTGGCTAGGCCTGCAAGCCGATTACGAGCTGGAACAAGCG
CACCGCGCGCTGGGCGACCTGCCATCGCGGATCAAGCGGCTGGCGGCTTGA
ATGACAGTCCTACCCAACATCCACCCTGGTGAAATCCTGCTTGAGGAGTTCCTCGAGCCGATGGGCATCAGCCAGAACGC
ATTGGCGCGGGCCACCGGTGTGCCGCCGCGCCGTATCAACGAAATCGTGTTGGGCAAGCGCGGCATCACCGCCGACACCG
CCGTGCGCCTGGCTGCAGCGCTGTGCACGACCGAGCGCTTCTGGCTAGGCCTGCAAGCCGATTACGAGCTGGAACAAGCG
CACCGCGCGCTGGGCGACCTGCCATCGCGGATCAAGCGGCTGGCGGCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A663AYG0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6P1V3Q9 |