Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 45174..45696 Replicon plasmid pB-8919_OXA-48
Accession NZ_CP094992
Organism Klebsiella pneumoniae strain SCPM-O-B-8919 (12PKP/19c)

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag KF986_RS26315 Protein ID WP_004181778.1
Coordinates 45412..45696 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5Q9LM53
Locus tag KF986_RS26310 Protein ID WP_025368601.1
Coordinates 45174..45422 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KF986_RS26290 (KF986_026290) 40384..41205 - 822 WP_004026535.1 hypothetical protein -
KF986_RS26295 (KF986_026295) 41267..41620 - 354 WP_004181774.1 hypothetical protein -
KF986_RS26300 (KF986_026300) 41765..42751 - 987 WP_025368599.1 hypothetical protein -
KF986_RS26305 (KF986_026305) 43085..44884 - 1800 WP_088678991.1 ATP-dependent helicase -
KF986_RS26310 (KF986_026310) 45174..45422 + 249 WP_025368601.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KF986_RS26315 (KF986_026315) 45412..45696 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KF986_RS26320 (KF986_026320) 45926..47152 + 1227 WP_025368602.1 RNA-guided endonuclease TnpB family protein -
KF986_RS26325 (KF986_026325) 47438..47863 - 426 WP_040120489.1 IS200/IS605 family transposase -
KF986_RS26330 (KF986_026330) 47900..49126 + 1227 WP_025368604.1 RNA-guided endonuclease TnpB family protein -
KF986_RS26335 (KF986_026335) 49192..50318 - 1127 Protein_66 conjugal transfer protein TraG N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaOXA-48 / catA1 / blaOXA-1 / aac(6')-Ib-cr / blaTEM-1B / qnrS1 / blaCTX-M-15 / ant(2'')-Ia / ant(3'')-Ia / qacE / sul1 iucA / iucB / iucC / iucD / iutA / rmpA2 1..326663 326663


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T240906 WP_004181778.1 NZ_CP094992:45412-45696 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T240906 NZ_LT853885:2004259-2004678 [Xanthomonas fragariae]
ATGATTGTCTTGGATACGAATGTAGTCTCCGAGGCGATAAAACCCGAACCCAACCCGGCCGTGCGAGCTTGGTTGAATGA
GCAGGTAGCGGAAACCCTCTACCTGTCCAGCGTGACGCTTGCCGAACTGCTGTTCGGCATCGGCGCGCTGCCGAACGGGA
AACGTAAGAAAGGCCTGGGCGAAGCCCTGGACGGCTTGCTCGAACTGTTCGGCGAGCGGGTGCTGATGTTCGACACCGAA
GCGGCTCGCCATTATGCCGAGCTGGCGGTGAAGGCCCGCACAGCCGGGAAGGGTTTTCCAACACCTGACGGATATATTGG
GGCTATTGCGGCCTCCAAGGGATTTATCGTAGCAACACGCGACACCAGCCCTTTCGAAGCGGCTGGGCTTACTGTTATCA
ATCCTTGGAACCATCAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8906.12 Da        Isoelectric Point: 3.8206

>AT240906 WP_025368601.1 NZ_CP094992:45174-45422 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGHIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT240906 NZ_LT853885:2004008-2004262 [Xanthomonas fragariae]
ATGGCAATCCTGACAGTGCGGAATGTGCCCGACGAGGTGCATCGCGCTCTGCGCTTACGGGCCGCCGAGCATGGCCGCAG
TACAGAGGCGGAGGTCCGCGAGATTCTGGAGAGTGCAGTTAAGTCAGAAAAGCGCATCCGCATGGGCGACGCGTTGGCGG
AGCTTGGCCGCCAAGTAGTGCTGACAAACGATGATTTCGCAGTGTTGGACCAGGTGCGCGACAAGGTGCCGGCAGAACCG
ATGAGGTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q9LM53

References